Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. Hras Antibody

Hras Antibody

  • 货号：
    CSB-PA15539A0Rb
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: Hras antibody at 2µg/ml
      Lane 1: 293T whole cell lysate
      Lane 2: Mouse brain tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 22 kDa
      Observed band size: 22 kDa
    • Immunohistochemistry of paraffin-embedded human lymphoid tissue using CSB-PA15539A0Rb at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Rattus norvegicus (Rat) Hras Polyclonal antibody
  • Uniprot No.：
    P20171
  • 基因名：
  • 别名：
    Hras antibody; Hras1 antibody; GTPase HRas antibody; H-Ras-1 antibody; Transforming protein p21 antibody; c-H-ras antibody; p21ras) [Cleaved into: GTPase HRas antibody; N-terminally processed] antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Rat, Mouse, Human
  • 免疫原：
    Recombinant Rat GTPase HRas protein (2-186AA)
  • 免疫原种属：
    Rattus norvegicus (Rat)
  • 标记方式：
    Non-conjugated

    本页面中的产品，Hras Antibody (CSB-PA15539A0Rb)，的标记方式是Non-conjugated。对于Hras Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA15539B0Rb Hras Antibody, HRP conjugated ELISA
    FITC CSB-PA15539C0Rb Hras Antibody, FITC conjugated
    Biotin CSB-PA15539D0Rb Hras Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
  • 基因功能参考文献：
    1. Together, these results suggest a novel mechanism regulating PATZ1 expression based on the upregulation of miR-29b expression induced by Ras oncogene. PMID: 27125250
    2. H-ras isoform mediates protection against pressure overload-induced cardiac dysfunction in part through activation of AKT/PI3K signaling pathway. PMID: 28193718
    3. Phenotypic Screening Identifies Protein Synthesis Inhibitors as H-Ras-Nanocluster-Increasing Tumor Growth Inducers. PMID: 26568031
    4. H-Ras mediates the inhibitory effect of epidermal growth factor on the epithelial Na+ channel PMID: 25774517
    5. Data indicate that numerous proteins that are up-regulated in H-ras(G12V) transgenic rat pancreatic ductal adenocarcinoma (PDAC) are also up-regulated in human PDAC; therefore, this rat model can be used for diagnostic biomarkers for this disease. PMID: 23648844
    6. Fe(2+)-generated O(2) mediates p21(ras) and TAK1 activation via PTP inhibition and Lys(63)-polyUb of TRAF6 in caveosomes for proinflammatory M1 activation in hepatic macrophages PMID: 22829592
    7. The proto-oncogenic H-Ras is directly involved in the promotion of muscle differentiation via PI3K and its downstream signaling pathways. PMID: 20603646
    8. Data show that Myc repressed Ras-induced senescence, and that Cdk2 interacted with Myc at promoters, where it affected Myc-dependent regulation of genes, including those of proteins known to control senescence. PMID: 19966300
    9. We examined if H-Ras and K-Ras proteins, which are distributed across different plasma membrane microdomains, have equal access to the endocytic compartment and whether this access is necessary for downstream signaling. PMID: 12077341
    10. A positive regulatory role of Ras is observed in AMPA receptor-mediated synaptic transmission in hippocampal pyramidal neurons. PMID: 12824760
    11. Functional activation of H-Ras might be one of the signaling steps involved in glucose-induced capillary cell apoptosis. PMID: 14988264
    12. Silencing of individual genes by DNA methylation is controlled by HRAS oncogenic signalling pathways, yet the mechanisms responsible for initial target gene suppression are variable. PMID: 16568090
    13. H-ras suppresses integrin affinity via independent Raf and phospholipase C epsilon signaling pathways. PMID: 16895916
    14. analysis of tumor induction with expression plasmids for activated H-ras and c-myc PMID: 18218323
    15. Infection with M. arginini made rat and mouse embryo fibroblasts susceptible to transformation with oncogenic H-Ras PMID: 18408766
    16. induction of long-term potentiation triggered robust Ca2+-dependent Ras activation in single spines that decayed in approximately 5 minutes; Ras activity spread over approximately 10 micrometers of dendrite and invaded neighboring spines by diffusion PMID: 18556515
    17. trend of increased H-ras expression was observed in diabetic compared to normal rats during oncogenesis PMID: 19283661

    显示更多

    收起更多

  • 亚细胞定位：
    Cell membrane. Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus. Golgi apparatus membrane; Lipid-anchor.
  • 蛋白家族：
    Small GTPase superfamily, Ras family
  • 数据库链接：

    KEGG: rno:293621

    STRING: 10116.ENSRNOP00000022363

    UniGene: Rn.102180