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ICAM4 Antibody

  • 货号：
    CSB-PA619892ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA619892ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA619892ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ICAM4 Polyclonal antibody
  • Uniprot No.：
    Q14773
  • 基因名：
    ICAM4
  • 别名：
    CD242 antibody; CD242 antigen antibody; ICAM-4 antibody; Icam4 antibody; ICAM4_HUMAN antibody; Intercellular adhesion molecule 4 antibody; Landsteiner Wiener blood group glycoprotein antibody; Landsteiner-Wiener blood group glycoprotein antibody; LW antibody; LW blood group protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Intercellular adhesion molecule 4 protein (20-140AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is also a ligand for alpha-4/beta-1 and alpha-V integrins.
  • 基因功能参考文献：
    1. the effect of modulation of the cAMP-PKA-dependent pathway on ICAM-4 receptor activation PMID: 28076805
    2. Cytometry analysis evidenced a specific expression profile on reticulocytes of SCA infants, with notably an increased expression of the adhesion molecules Lu/BCAM, ICAM-4 and LFA-3, both in percentage of positive cells and in surface density. PMID: 26137540
    3. Seven variant ICAM4 alleles were found, distinct from the wild-type ICAM4 allele (GenBank KF712272), known as LW*05 and encoding LW(a) . PMID: 24673173
    4. Data from differentiating cultured erythroid precursor cells suggest that RhAG (Rh-associated glycoprotein) knockdown abolishes Rh blood group expression (ICAM4; RhoD [ras homolog family member D]; CD47 Rh-related antigen) in erythroid cells. PMID: 23417980
    5. Erythrocyte plasma membrane-bound ERK1/2 activation promotes ICAM-4-mediated sickle red cell adhesion to endothelium. PMID: 22147898
    6. In a transgenic mouse model of sickle cell disease ICAM-4 is implicated in abnormal adhesiveness of erythrocytes to endothelium. PMID: 20015873
    7. LWa allele occurs with incidence of 100% of donors in this study, while LWb allele has not been found in Chinese population. PMID: 18549656
    8. ICAM-4 as the first red blood cells protein ligand of platelets that may have relevant physiological significance PMID: 12477717
    9. binds to the I domains of the CD11a/CD18 and CD11b/CD18 leukocyte integrins PMID: 12694184
    10. 12 single amino-acid changes in ICAM4 affected the interaction of ICAM-4 with alpha(V) integrins PMID: 14551135
    11. LW on sickle but not on normal erythrocytes undergoes increased PKA-dependent serine phosphorylation as a result of activation. The major counter receptor for LW was identified as the alphavbeta3 integrin on ECs PMID: 15308566
    12. Different integrins bind to different but partly overlapping sites on ICAM4, and ICAM4 may accommodate multiple integrin receptors present on leukocytes, platelets and endothelial cells. PMID: 15355350
    13. Review. LW antigen contributes to RBC adhesion, thrombosis, and (in sickle cell disease) vaso-occlusion. PMID: 16564726
    14. We show that ICAM-4 functions as a ligand for the monocyte/macrophage-specific CD11c/CD18. Deletion of the individual immunoglobulin domains of ICAM-4 demonstrated that both its domains contain binding sites for CD11c/CD18. PMID: 16985175
    15. LW play potentially pathophysiological roles in sickle cell disease PMID: 17609430

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  • 亚细胞定位：
    [Isoform Long]: Cell membrane; Single-pass type I membrane protein.; [Isoform Short]: Secreted.; Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Immunoglobulin superfamily, ICAM family
  • 组织特异性：
    Erythrocytes.
  • 数据库链接：

    HGNC: 5347

    OMIM: 111250

    KEGG: hsa:3386

    STRING: 9606.ENSP00000342114

    UniGene: Hs.706750