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ICK Antibody

  • 货号：
    CSB-PA891800LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: PC-3 whole cell lysate
      All lanes: ICK antibody at 3μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 72, 35 kDa
      Observed band size: 72 kDa
    • Immunohistochemistry analysis of human pancreatic cancer using CSB-PA891800LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ICK Polyclonal antibody
  • Uniprot No.：
    Q9UPZ9
  • 基因名：
    ICK
  • 别名：
    CILK1 antibody; ICK antibody; KIAA0936Serine/threonine-protein kinase ICK antibody; EC 2.7.11.1 antibody; Ciliogenesis associated kinase 1 antibody; Intestinal cell kinase antibody; hICK antibody; Laryngeal cancer kinase 2 antibody; LCK2 antibody; MAK-related kinase antibody; MRK antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Serine/threonine-protein kinase ICK protein (150-275AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ICK Antibody (CSB-PA891800LA01HU)，的标记方式是Non-conjugated。对于ICK Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA891800LB01HU ICK Antibody, HRP conjugated ELISA
    FITC CSB-PA891800LC01HU ICK Antibody, FITC conjugated
    Biotin CSB-PA891800LD01HU ICK Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Required for ciliogenesis. Phosphorylates KIF3A. Involved in the control of ciliary length. Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips. May play a key role in the development of multiple organ systems and particularly in cardiac development. Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner and this regulation requires its kinase activity.
  • 基因功能参考文献：
    1. Our data provide evidence that heterozygous variants in ICK caused juvenile myoclonic epilepsy in 7% of the patients included in our analysis. Variant ICK affects cell processes that help explain microdysgenesis and polyspike networks observed on EEG in juvenile myoclonic epilepsy. PMID: 29539279
    2. These data identify ICK as an short rib polydactyly syndromes (SRPS)-associated gene and reveal that abnormalities in signalling pathways contribute to defective skeletogenesis PMID: 27466187
    3. findings suggest that increased ICK expression/activity in response to protein deprivation likely provides a novel protective mechanism to limit apoptosis and support compensatory mucosal growth under nutritional stress. PMID: 25184386
    4. the expressions of ICK/MAK/MOK proteins in the intestinal tract can be differentially and dynamically regulated, implicating a significant functional diversity within this group of protein kinases. PMID: 24244486
    5. In glioblastoma cells with deregulated high levels of CCRK, its depletion restores cilia through ICK and an ICK-related kinase MAK, thereby inhibiting glioblastoma cell proliferation. PMID: 23743448
    6. High ICK expression is associated with prostate cancer. PMID: 22761715
    7. an important role for ICK in modulating the activity of mTORC1 through phosphorylation of Raptor Thr-908. PMID: 22356909
    8. ICK may play a role in the development of multiple organ systems. R272Q has been associated with endocrine-cerebro-osteodysplasia and may explain loss of function since the R272Q mutant fails to localize at the nucleus and has diminished kinase activity PMID: 19185282
    9. Findings demonstrate an important role for ICK in proliferation and differentiation of intestinal epithelial cells. PMID: 19696144
    10. ICK and FBX9 are divergently transcribed from a bidirectional promoter that is GC-rich and contains a CpG island. PMID: 20459822
    11. PP5 (protein phosphatase 5)and CCRK (cell cycle-related kinase) are yin-yang regulators of T157 phosphorylation. ICK interacts with and phosphorylates human Scythe, an essential regulator of proliferation and apoptosis during mammalian development. PMID: 16954377
    12. ICK plays an important role in the regulation of proliferation and differentiation of intestinal epithelial cells. ICK may control G1 cell cycle progression by regulating expression of cell cycle regulators cyclin D1, c-Myc and p21Cip1. PMID: 19696144
    13. ICK is the prototype for a new group of MAPK-like kinases requiring dual phosphorylation at TDY motifs. PMID: 15988018

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  • 相关疾病：
    Endocrine-cerebroosteodysplasia (ECO)
  • 亚细胞定位：
    Nucleus. Cytoplasm, cytosol. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body.; [Isoform 2]: Cytoplasm.
  • 蛋白家族：
    Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
  • 组织特异性：
    Expressed in heart, brain, placenta, pancreas, thymus, prostate, testis, ovary, small intestine and colon, with highest levels in placenta and testis. Not detected in spleen. Also expressed in many cancer cell lines.
  • 数据库链接：

    HGNC: 21219

    OMIM: 612325

    KEGG: hsa:22858

    STRING: 9606.ENSP00000263043

    UniGene: Hs.417022