Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. IDH3B Antibody

IDH3B Antibody

  • 货号：
    CSB-PA05515A0Rb
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: IDH3B antibody at 2µg/ml
      Lane 1: Hela whole cell lysate
      Lane 2: Mouse kidney tissue
      Lane 3: Mouse gonadal tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 43, 42, 26 kDa
      Observed band size: 43 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) IDH3B Polyclonal antibody
  • Uniprot No.：
    O43837
  • 基因名：
    IDH3B
  • 别名：
    FLJ11043 antibody; H-IDHB antibody; Idh3B antibody; IDH3B_HUMAN antibody; Isocitrate dehydrogenase [NAD] subunit beta antibody; Isocitrate dehydrogenase [NAD] subunit beta; mitochondrial antibody; isocitrate dehydrogenase 3; beta subunit antibody; Isocitric dehydrogenase antibody; Isocitric dehydrogenase subunit beta antibody; MGC903 antibody; mitochondrial antibody; NAD(+)-specific ICDH antibody; NAD(+)-specific ICDH subunit beta antibody; NAD+-specific isocitrate dehydrogenase b subunit antibody; NAD+-specific isocitrate dehydrogenase beta antibody; OTTHUMP00000030023 antibody; OTTHUMP00000030024 antibody; RP46 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial protein (35-385AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，IDH3B Antibody (CSB-PA05515A0Rb)，的标记方式是Non-conjugated。对于IDH3B Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA05515B0Rb IDH3B Antibody, HRP conjugated ELISA
    FITC CSB-PA05515C0Rb IDH3B Antibody, FITC conjugated
    Biotin CSB-PA05515D0Rb IDH3B Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a structural role to facilitate the assembly and ensure the full activity of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers.
  • 基因功能参考文献：
    1. Human NAD-dependent isocitrate dehydrogenase (IDH) is a heterotetrameric mitochondrial enzyme with 2alpha:1beta:1gamma subunit ratio subunits shich share 40-52% identity in amino acid sequence. PMID: 20435888
    2. IDPm activity appears to be modulated through enzymatic glutathionylation and deglutathionylation during oxidative stress PMID: 15653693
    3. Asp192 is needed for optimal affinity of IDH beta subunit for nicotinamide-adenine dinucleotide (NAD) substrate, but is not critical for catalysis. PMID: 17432878
    4. Homozygous for loss-of-function mutations in IDH3B is associated with retinitis pigmentosa. PMID: 18806796
    5. The point mutations of isocitrate dehydrogenase are essentially unique to gliomas. PMID: 19498431

    显示更多

    收起更多

  • 相关疾病：
    Retinitis pigmentosa 46 (RP46)
  • 亚细胞定位：
    Mitochondrion.
  • 蛋白家族：
    Isocitrate and isopropylmalate dehydrogenases family
  • 数据库链接：

    HGNC: 5385

    OMIM: 604526

    KEGG: hsa:3420

    STRING: 9606.ENSP00000370223

    UniGene: Hs.436405