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IKZF2 Antibody

  • 货号：
    CSB-PA008257
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of Hela cells using Helios Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q9UKS7
  • 基因名：
    IKZF2
  • 别名：
    ANF1A2 antibody; HELIOS antibody; IKAROS family zinc finger 2 antibody; Ikaros family zinc finger protein 2 antibody; IKZF 2 antibody; IKZF2 antibody; IKZF2_HUMAN antibody; MGC34330 antibody; Zinc finger DNA binding protein Helios antibody; Zinc finger protein Helios antibody; Zinc finger protein subfamily 1A 2 antibody; ZNF1A2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Helios.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Associates with Ikaros at centromeric heterochromatin.
  • 基因功能参考文献：
    1. The results suggested that increased methylation of Foxp3 Treg-specific demethylated region sequence and altered Helios gene expression in peripheral whole blood may have a role in the pathogenesis of rheumatoid arthritis via their effects on Regulatory T cell stability. PMID: 29851536
    2. Helios mRNA is down-regulated in Treg cells of patients with hypertension. PMID: 30074152
    3. mRNA expression of Helios was decreased in CD4+ T cells from patients with acute coronary syndrome. PMID: 29259350
    4. High expression of TIGIT and Helios identifies CD4+ T cells with impaired immunological functions, primarily among patients with an advanced stage of Sezary syndrome. PMID: 27592800
    5. The results show that high vs. low expression of Nrp-1 or Helios does not unequivocally identify Treg clones of thymic or peripheral origin. PMID: 26495986
    6. Helios could be considered a more reliable marker for distinguishing thymic derived Regulatory T (tTreg) cells or peripherally induced Treg cells than Nrp1. PMID: 25586548
    7. expression is not affected in diGeorge syndrome PMID: 25008482
    8. Forkhead box protein 3(+) regulatory T cells and Helios(+) subset in perinatally acquired HIV. PMID: 25425428
    9. Ectopic expression of ATL-type Helios isoform as well as knockdown of normal Helios or Ikaros promoted T-cell growth. PMID: 23600753
    10. Foxp3+ Helios+ regulatory T cells are expanded in active systemic lupus erythematosus. PMID: 23264341
    11. large number of ex vivo expanded functional Treg can be obtained from long-term T1D patients, although fewer expanded Treg expressed a high level of Helios PMID: 23409157
    12. A differential role for monocyte subsets in control of Helios(+/-) Treg development that is mediated by distinct inflammatory cytokines. PMID: 23365462
    13. Helios+ and Helios- cells coexist within the natural FOXP3+ T regulatory cell subset in humans. PMID: 23359504
    14. Presence of Helios-positive regulatory T (Treg) cells may maintain susceptibility to helminth infection on the C57BL/6 mouse background. PMID: 22753928
    15. Data found that Helios-negative T cells are enriched for naive T cell phenotypes and vice versa. Moreover, Helios can be induced during T cell activation and proliferation, but regresses in the same cells under resting conditions. PMID: 21918685
    16. Expanded peripheral FoxP3+ Tregs in untreated renal cell carcinoma patients co-express Helios. Interestingly, IL-2 administration results in expansion of FoxP3+Helios+ natural Tregs (nTregs) significantly more than FoxP3+Helios- iTregs. PMID: 21570917
    17. found that suppression of Helios message in CD4(+)CD25(+) T cells significantly attenuates their suppressive function. PMID: 20226531
    18. Novel short isoforms of Helios are overexpressed in a patient with T-cell acute lymphoblastic leukemia and may contribute to the development of T-cell malignancies. Data for unaltered Helios indicates tumor suppressor function. PMID: 11937265
    19. suggest a critical role for Helios in the mechanism of leukemogenesis PMID: 17297655

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Ikaros C2H2-type zinc-finger protein family
  • 数据库链接：

    HGNC: 13177

    OMIM: 606234

    KEGG: hsa:22807

    STRING: 9606.ENSP00000410447

    UniGene: Hs.604950