IL10RA Antibody

1. This case report and case-control study explores the role of IL10RA and its deficiency in the development of the immune system and inflammatory bowel diseases. PMID: 28644354
2. We identified 32 compound heterozygous mutations and 9 homozygous mutations in IL10 receptor subunit alpha and 1 homozygous mutation in IL10 receptor subunit beta. Among these mutations, 10 novel mutations were identified, and 6 pathogenic mutations had been previously described. In patients with IL10 receptor subunit alpha mutations, c.301C>T (p.R101RW) and c.537 G>A (p.T179T) were the most common mutations. PMID: 28267044
3. these findings provide a novel mechanism by which microbial-derived butyrate promotes barrier through IL-10RA-dependent repression of claudin-2 PMID: 28893958
4. Expression of IL10R subunits within the leukocyte population (CD45(+) cells) was significantly higher in primary brain tumors than in metastases. PMID: 28982901
5. This study showed that lack of association with schizophrenia was detected for IL10 and IL10RA single polymorphisms and haplotypes. PMID: 27397081
6. The IL-10RA rs9610 A allele was increased in rheumatoid arthritis (RA) patient group compared with control subjects. Interestingly, significant differences were detected both in the allele and genotype frequencies of rs9610 between anti-CCP (anti-cyclic citrullinated peptide) positive patients and anti-CCP negative patients. The findings suggest that IL-10RA rs9610 polymorphism might contribute to RA susceptibility. PMID: 27796662
7. These results suggest that S138G loss-of-function polymorphism of the IL-10R1 may be important risk factor in increasing susceptibility to multiple sclerosis. PMID: 28225209
8. Results reveal the structure of box1 from class II cytokine receptors IFNLR1 and IL10RA bound to the FERM-SH2 domain of human JAK1, identifying a consensus motif for JAK1 interaction. PMID: 27133025
9. a JAK2 Inhibitor Suppresses a BCL6-dependent IL10RA/JAK2/STAT3 Pathway in High Grade B-cell Lymphoma. PMID: 27268052
10. genetic association study in cohort of infants/children: Data suggest perianal fistulas are exhibited in patients with very early-onset inflammatory bowel disease with IL10 receptor mutations (IL10RA/B); prognosis and response to treatment are poor. PMID: 25373860
11. IL-10Ralpha expression is post-transcriptionally regulated by miR-15a, miR-185, and miR-211 in melanoma PMID: 26631117
12. SNP3 polymorphism is associated with myocardial infarction; may generate some conformational rearrangements of the IL-10R1 receptor domain which affects IL-10 complex binding and alters its downstream signal PMID: 24566517
13. High IL10RA expression is associated with diffuse large B-cell lymphoma. PMID: 25733167
14. Inflammatory bowel disease (IBD) in infancy is phenotypically and genetically different disease entity from adult-onset or older child-onset IBD. It has a strong association with IL-10 receptor gene. PMID: 24785691
15. IL10R1 loss-of-function A536/S138G polymorphism may contribute to recurrent pregnancy loss pathogenesis PMID: 24689510
16. Very early onset inflammatory bowel disease associated with aberrant trafficking of IL-10R1 and cure by T cell replete haploidentical bone marrow transplantation. PMID: 24519095
17. Mutations in the IL10RA gene is associated with ulcerative colitis. PMID: 24216686
18. Case Report: pediatric ulcerative colitis with a novel point mutation within the IL10RA promoter (the -413G->T), inherited from his mother. PMID: 24379584
19. This report confirms the genetic defect of IL-10RA in neonatal-onset inflammatory bowel disease. PMID: 23839161
20. IFN-gamma selectively induced the expression of IL-10R1 on intestinal epithelia, predominantly on the apical membrane of polarized epithelial cells. PMID: 24367025
21. A mutation in TLR4 (rs4986790) and IL10RA (rs22291130) was significantly associated with Mycobacterium avium subspecies paratuberculosis-positive Crohn's disease patients. PMID: 23455702
22. 5 patients with an IL-10R1 or IL-10R2 deficiency developed B-cell non-Hodgkin lymphoma between the ages of 5 and 6 years (which was recurrent in 1 patient). PMID: 24089328
23. IL10RA polymorphisms are associated with ulcerative colitis. PMID: 22550014
24. In the Chinese Han population, missense SNPs within the exons of the IL-10R1 gene do not contribute to the development of systemic lupus erythematosus PMID: 22652629
25. The results suggest that genetic polymorphisms in TNF and IL10RA genes may modify the association between blood transfusion and NHL risk. PMID: 22649007
26. IL-10R1 is a novel substrate of betaTrCP-containing ubiquitin E3 ligase, a novel negative regulatory mechanism that may potentially affect IL-10 function PMID: 22087322
27. We found an IL10R variant, which may be associated with a decreased response to the cytokine in one patient. PMID: 22155628
28. IL-10R1 S138G loss-of-function polymorphism is associated with extrapulmonary tuberculosis risk development in Tunisia. PMID: 21553229
29. The haplotype -185/-116 of IL10 receptor alpha in combination with the haplotype -754/-750 of IL10 receptor beta contributed towards mild malaria. PMID: 21814839
30. IL10R1-G330R does not alter surface expression but duration of STAT phosphorylation, indicating that the position of G330 is important in stabilizing the STAT signal. PMID: 21654841
31. linkage disequilibrium (LD) blocks were formed in IL10 and IL10RA PMID: 21532858
32. IL-10R1 expression on CD4+ T cells and signalling in PBMCs were down-regulated in lupus nephritis (LN) patients, indicating that IL-10 and its receptor may have a special role in LN pathogenesis PMID: 21635228
33. Besides overall immune health, host genetic factors influence mortality, retinitis progression, and retinal detachment in patients with AIDS and CMV retinitis that are receiving HAART. PMID: 21396623
34. in the Lebanese population, the loss-of-function allele IL-10R1-S138G (SNP3) is unlikely to provide a protective effect against ulcerative colitis and that both IL-10R1 variants do not correlate with inflammatory bowel disease PMID: 20186944
35. G carriers for the -536AG IL-10R1 gene polymorphism had higher systolic and diastolic pressures, and IL-10 levels; and obese G carriers had an increased waist-to-hip ratio. PMID: 19798061
36. cmvIL-10 forms a disulfide-linked homodimer that binds two sIL-10R1 molecules. PMID: 12093920
37. IL-10 receptor stimulated the rapid translocation of IL-10E1 to the cell nucleus and the activation of TIMP-1 expression in primary human prostate tumor cell lines. PMID: 12496489
38. Abnormal interleukin 10Ralpha expression contributes to the maintenance of elevated cyclooxygenase-2 in non-small cell lung cancer cells. PMID: 12591723
39. This investigation reveals three previously unrecognized polymorphisms of IL-10R1 (SNP3, SNP4, and SNP5), two of which result in an amino acid substitution; substitution in S138G variant may interfere with binding of IL-10 to IL-10R1. PMID: 12759436
40. Homozygosity of the IL-10R1 G330R allele is associated with schizophrenia and may contribute to the expression of disease phenotype in susceptible individuals. PMID: 17066477
41. Genetic variation in IL-10RA/IL-22 genes may play a modulatory role in the outcome of hepatitis C infection. PMID: 17845543
42. The IL-4R Ile50/Ile50 and IL-10R2 G520/G520 and G520/A520 genotypes were shown to determine the susceptibility to SLE (systemic lupus erythematosus)in a Chinese population PMID: 17988330
43. The peripheral blood neutrophils of septic patients constitutively display abundant levels of surface IL-10R1. PMID: 18308712
44. IL-10R is associated with the progression of the renal cell carcinoma PMID: 18344594
45. Data demonstrate a significant relation between cervical concentrations of IL-10 and single nucleotide polymorphisms in the IL-10 receptor alpha and beta genes. PMID: 18674658
46. The IL-10R1 S138G loss-of-function allele and ulcerative colitis are reported. PMID: 18800073
47. a variant rs17121510 in the interleukin-10 receptor antagonist (IL-10RA) gene for allele (p = 0.01) and genotype (p = 3.34x10(-4)) may have a role in preterm birth PMID: 18818748
48. IL-10R1 variants differentially reduce the signaling activity of cmvIL-10 PMID: 19016528
49. Mutations in genes encoding the IL10R subunit proteins were found in patients with early-onset enterocolitis, involving hyperinflammatory immune responses in the intestine. PMID: 19890111
50. The capacity of neutrophils to respond to IL-10, as assessed by Stat3 tyrosine phosphorylation, SOCS-3 expression, and modulation of cytokine production, is dependent on the level of expression of IL-10R1. PMID: 11490020

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HGNC: 5964

OMIM: 146933

KEGG: hsa:3587

STRING: 9606.ENSP00000227752

UniGene: Hs.504035