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  4. IL17B Antibody

IL17B Antibody

  • 货号：
    CSB-PA648539
  • 规格：
    ￥880
  • 图片：
    • Immunohistochemical analysis of paraffin-embedded human-small-intestine, antibody was diluted at 1:200
  • 其他：

产品详情

  • Uniprot No.：
    Q9UHF5
  • 基因名：
  • 别名：
    Cytokine like protein Zcyto7 antibody; Cytokine Zcyto7 antibody; IL 17B antibody; IL 20 antibody; IL-17B antibody; IL-20 antibody; IL17B antibody; IL17B_HUMAN antibody; IL20 antibody; Interleukin 17 beta antibody; Interleukin 17B antibody; Interleukin 20 antibody; Interleukin-17B antibody; Interleukin-20 antibody; MGC138900 antibody; MGC138901 antibody; Neuronal interleukin 17 related factor antibody; Neuronal interleukin-17-related factor antibody; NIRF antibody; ZCYTO7 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Rat
  • 免疫原：
    Synthetic peptide from Human protein at AA range: 1-50
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 纯化方式：
    The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC,ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC IHC-p:1:50-300
    ELISA 1:10000-20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1.
  • 基因功能参考文献：
    1. The results indicate that the IL-17B/IL-17RB signaling can promote the growth and migration of tumor cells. PMID: 27146881
    2. Our data revealed a new mechanism that IL-17B enhanced the progression of gastric cancer by activating mesenchymal stem cells. PMID: 28145881
    3. Segregation analysis revealed that variants c.475T>G in SKP1, c.671G>A in PROB1, and c.527G>A in IL17B in the 5q31.1-q35.3 linkage region, and c.850G>A in HKDC1 in the 10q22 locus completely segregated with the phenotype in the studied Keratoconus family PMID: 27703147
    4. This comprehensive review details the recognition of activity, signaling, and the roles of IL17B-IL17RB in breast cancer have caused to determination of new therapeutic mechanisms--{REVIEW} PMID: 28160754
    5. Studies indicate that interleukin 17 (IL-17B)/interleukin 17 receptor B (IL-17RB) signaling is essential for pancreatic cancer malignancy. PMID: 26285835
    6. IL-17B-IL-17RB signaling promotes pancreatic cancer malignancy. PMID: 25732306
    7. Results show that amplified signaling of interleukin-17 receptor B (IL-17RB) and its ligand IL-17B promot tumorigenicity in breast cancer cells and impeded acinus formation in immortalized normal mammary epithelial cells. PMID: 23851503
    8. IL-17B can enhance the effects of TNF-alpha on the production of cytokines and chemokines that control immune cell trafficking and neutrophil homeostasis in the inflamed tissues. PMID: 24056520
    9. IL-17A, IL-17B, IL-17F and IL-23 in systemic lupus erythematosus patients were examined and the correlation between levels of the investigated cytokines and VEGF, PIGF, as well as number of endothelial cells, was investigated. PMID: 23661335
    10. expression and functional study of IL-17B PMID: 22394632
    11. IL-17 may play an important role in the occurrence of nasal polyps by overexpression. PMID: 16805377

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    IL-17 family
  • 组织特异性：
    Expressed in adult pancreas, small intestine, stomach, spinal cord and testis. Less pronounced expression in prostate, colon mucosal lining, and ovary.
  • 数据库链接：

    HGNC: 5982

    OMIM: 604627

    KEGG: hsa:27190

    STRING: 9606.ENSP00000261796

    UniGene: Hs.156979