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  4. IL21R Antibody

IL21R Antibody

  • 货号：
    CSB-PA313276
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA313276(IL21R Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA313276(IL21R Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q9HBE5
  • 基因名：
  • 别名：
    CD360 antibody; IL 21R antibody; IL-21 receptor antibody; IL-21R antibody; IL21 receptor antibody; IL21R antibody; IL21R_HUMAN antibody; Interleukin 21 receptor antibody; Interleukin-21 receptor antibody; MGC10967 antibody; NILR antibody; Novel interleukin receptor antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Fusion protein of Human IL21R
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    This is a receptor for interleukin-21.
  • 基因功能参考文献：
    1. The number of IL-2-dependent FoxP3(+) regulatory T cells is increased in the peripheral blood of human patients with loss-of-function mutations in the IL-21 receptor (IL-21R). PMID: 28303891
    2. bone marrow monocytes from multiple myeloma patients show distinct features compared to those from patients with indolent monoclonal gammopathies, supporting the role of IL21R over-expression by bone marrow CD14(+) cells in enhanced osteoclast formation. PMID: 28057743
    3. Report increased levels of IL-21R in the skeletal muscle endothelial cells of patients with peripheral arterial disease compared to control individuals. PMID: 26705256
    4. expression of IL-21 and IL-21R were up-regulated in autoimmune thyroid disease and may be involved in the pathogenesis of the disease through augmenting aberrant immune cascade PMID: 25647271
    5. interleukin-21 receptor deficiency is associated with Severe Combined Immunodeficiency. PMID: 25398835
    6. IL-21R on B cells is upregulated in allergic rhinitis patients when compared to controls. IL-21/IL-21R may be involved in the regulation of allergic reactions through the inhibition of IgE. PMID: 25007029
    7. IL-21/IL-21R could act as potential biomarkers presenting early systemic sclerosis skin lesions severity. PMID: 25500255
    8. STAT3 signaling downstream of IL-23R and IL-21R has a role in controlling human mucosal-associated invariant T cells and NKT cell numbers PMID: 25941256
    9. Human neutrophils in peripheral blood express functional IL-21 receptors. PMID: 24728504
    10. IL-21R gene polymorphisms and serum IL-21 levels predict virological response to interferon-based therapy in Asian chronic hepatitis C patients. PMID: 23296193
    11. Abundant expression of interleukin-21 receptor in follicular lymphoma cells is associated with more aggressive disease. PMID: 23098230
    12. Data suggest that IL21 rs2221903 and IL21R rs3093301 polymorphisms may, independently or interactively, affect the susceptibility to and/or persistence of HBV infection potentially through altering IL-21 and IgE production. PMID: 23354321
    13. The IL-21R/STAT3 pathway is required for many aspects of human CD8(+) T-cell behavior but in some cases can be compensated by other signals. PMID: 23830147
    14. Human monocyte-like THP-1 cells express two IL-21 receptor components, CD132 (gammac) and IL-21Ralpha, on their cell surface, as assessed by flow cytometry. PMID: 23396946
    15. human IL-21R deficiency causes an immunodeficiency and highlights the need for early diagnosis PMID: 23440042
    16. For risk-factor studies, anti-citrullinated peptide antibody-positive (CCP)-negative rheumatoid arthritis patients can be studied as one group via measurement of their IL-21 and IL-21 receptor levels. PMID: 22032620
    17. Crystal structure of IL-21 binding to IL-21R reveals that the WSXWS motif of IL-21R is C-mannosylated at the first tryptophan. PMID: 22235133
    18. IL21R and vezatin were also cleaved in apoptotic HeLa cells with the cleavage sites Asp344, Asp655 and Asp53. PMID: 21524651
    19. Data suggest that the association of 2009 H1N1 vaccine-induced Ab responses with IL-21/IL-21R upregulation and with development of memory B cells and plasmablasts has implications for future research in vaccine design. PMID: 21531891
    20. These findings suggest role(s) for IL-21 in both the acute and chronic stages of multiple sclerosis via direct effects on T and B lymphocytes and, demonstrated for the first time, also on neurons. PMID: 21281812
    21. parathyroid hormone (PTH) and interleukin 21 receptor (IL21R), achieved consistent association results for bone mineral density in both discovery and replication samples. PMID: 19874204
    22. IL-21R is expressed in follicular lymphoma cells from early diagnosed, untreated patients. It mediates apoptosis. It is heterogenously expressed by human FL cell lines bearing the t(14;18) translocation. PMID: 20193734
    23. This report provides the first evidence that WSB-2 is a regulator of IL-21R expression and IL-21-induced signal transduction. PMID: 20059963
    24. IL-21R is associated with the activated phenotype of rheumatoid arthritis synovial fibroblasts independently of the major proinflammatory cytokines IL-1beta and TNFalpha, but not with the destruction of articular cartilage and bone. PMID: 15146416
    25. The up-regulation of IL-21R in keratinocytes indicates that its expression pattern is not only altered but it appears to be independent of key cytokines that are operant in systemic scleosis. PMID: 15751077
    26. TCR-induced IL-21R expression is driven by TCR-mediated augmentation of Sp1 protein levels and may partly depend on the dephosphorylation of Sp1 PMID: 16260592
    27. surface IL-21 receptor is expressed at variable levels by chronic lymphocytic leukemia B cells PMID: 16391014
    28. IL-21 differentially regulates IL-4-induced IgE production, via its growth- and differentiation-promoting capacities on isotype- committed B cells, & via its ability to induce IFNg production; the outcome depends on the presence of a IL-21R polymorphism. PMID: 17015683
    29. IL-21R is overexpressed in the inflamed synovial membrane and in peripheral blood or synovial fluid leukocytes of RA patients. Thus, blockade of IL-21R signalling pathway may have a therapeutic potential in acute RA patients. PMID: 17032244
    30. Data suggest a contribution of IL21 and IL21R to genetic susceptibility to type 1 diabetes and possible involvement of IL-21 and its receptor system in the disease pathogenesis. PMID: 17462506
    31. Follicular lymphoma cells showed exceptionally high IL-21R expression. IL-21 induced apoptosis in follicular lymphoma cells expressing high levels of IL-21 receptor. PMID: 17624663
    32. These results suggest an important role for IL-21R in the mobilization of skin dendritic cells to draining lymph nodes and the subsequent allergic response to epicutaneously introduced antigen. PMID: 19075398
    33. analyzed the transcriptional differences between B-cell subsets by gene expression profiling, and identified 15 genes significantly correlated to survival/proliferation. Among them, IL-21R and TCL1 were highly expressed in naive B cells. PMID: 19230867
    34. Increased IL-21R is associated with inflammatory bowel disease. PMID: 19322899
    35. Tax1 transactivates the interleukin-21 (IL-21) and its receptor (IL-21R) genes in human T-cells. PMID: 19617351
    36. A polymorphism within IL21R confers risk for systemic lupus erythematosus. PMID: 19644854

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  • 相关疾病：
    IL21R immunodeficiency (IL21RID)
  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Type I cytokine receptor family, Type 4 subfamily
  • 组织特异性：
    Selectively expressed in lymphoid tissues. Most highly expressed in thymus and spleen.
  • 数据库链接：

    HGNC: 6006

    OMIM: 605383

    KEGG: hsa:50615

    STRING: 9606.ENSP00000338010

    UniGene: Hs.210546