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IMPAD1 Antibody

  • 货号：
    CSB-PA136380
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA136380(IMPAD1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA136380(IMPAD1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q9NX62
  • 基因名：
  • 别名：
    IMPAD1 antibody; IMPA3 antibody; Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase antibody; Golgi-resident PAP phosphatase antibody; gPAPP antibody; EC 3.1.3.7 antibody; Inositol monophosphatase domain-containing protein 1 antibody; Myo-inositol monophosphatase A3 antibody; Phosphoadenosine phosphate 3'-nucleotidase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human IMPAD1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Exhibits 3'-nucleotidase activity toward adenosine 3',5'-bisphosphate (PAP), namely hydrolyzes adenosine 3',5'-bisphosphate into adenosine 5'-monophosphate (AMP) and a phosphate. May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation. Has no activity toward 3'-phosphoadenosine 5'-phosphosulfate (PAPS) or inositol phosphate (IP) substrates including I(1)P, I(1,4)P2, I(1,3,4)P3, I(1,4,5)P3 and I(1,3,4,5)P4.
  • 基因功能参考文献：
    1. concluded that IMPAD1 should be screened for patients with Catel-Manzke and additional features PMID: 22887726
    2. Affected individuals carried homozygous missense mutations in IMPAD1, the gene coding for gPAPP, a Golgi-resident nucleotide phosphatase that hydrolyzes phosphoadenosine phosphate (PAP), the byproduct of sulfotransferase reactions, to AMP. PMID: 21549340
  • 相关疾病：
    Chondrodysplasia with joint dislocations, GPAPP type (CDP-GPAPP)
  • 亚细胞定位：
    Golgi apparatus. Golgi apparatus, trans-Golgi network membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Inositol monophosphatase superfamily
  • 数据库链接：

    HGNC: 26019

    OMIM: 614010

    KEGG: hsa:54928

    STRING: 9606.ENSP00000262644

    UniGene: Hs.438689