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IMPDH1 Antibody

  • 货号：
    CSB-PA22459A0Rb
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA22459A0Rb diluted at 1:600 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA22459A0Rb diluted at 1:600 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of Hela cells with CSB-PA22459A0Rb at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) IMPDH1 Polyclonal antibody
  • Uniprot No.：
    P20839
  • 基因名：
    IMPDH1
  • 别名：
    IMDH1_HUMAN antibody; IMP (inosine monophosphate) dehydrogenase 1 antibody; IMP dehydrogenase 1 antibody; IMPD 1 antibody; IMPD antibody; IMPD1 antibody; IMPDH 1 antibody; IMPDH I antibody; IMPDH-I antibody; Impdh1 antibody; Inosine 5' monophosphate dehydrogenase 1 antibody; Inosine monophosphate dehydrogenase 1 antibody; Inosine-5''-monophosphate dehydrogenase 1 antibody; LCA11 antibody; RP10 antibody; sWSS2608 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Inosine-5\'-monophosphate dehydrogenase 1 protein (191-281AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，IMPDH1 Antibody (CSB-PA22459A0Rb)，的标记方式是Non-conjugated。对于IMPDH1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA22459B0Rb IMPDH1 Antibody, HRP conjugated ELISA
    FITC CSB-PA22459C0Rb IMPDH1 Antibody, FITC conjugated
    Biotin CSB-PA22459D0Rb IMPDH1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:500-1:1000
    IF 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
  • 基因功能参考文献：
    1. We have found that the rs2278294 G allele exerts statistically significant inhibition on post-kidney transplant body mass index gain PMID: 30056902
    2. In our cohort of >300 familial cases of autosomal-recessive retinitis pigmentosa, PKRP004 is the only family harboring a mutation in IMPDH1. PMID: 25439607
    3. Expression of IMPDH mRNA after mycophenolate administration in male volunteers. PMID: 25105143
    4. A novel mutation, p.L270R in IMPDH1, was found to be retinitis pigmentosa-causing in one family. PMID: 23534816
    5. p53 has a novel function in regulating purine biosynthesis, aided by miR-34a-dependent IMPDH repression. PMID: 22301190
    6. IMPDH has a function in the retina, apparently independent of its enzymatic activity, mediated by retina-specific variants. PMID: 22183375
    7. IMPDH1 mutation is associated with retinitis pigmentosa. PMID: 21791244
    8. The mutation frequency of IMPDH1 gene of the Han population in Ganzhou city was similar as approximately 2-5% of the autosomal dominant retinitis pigmentosa cases among Americans of European origin and Europeans. PMID: 20238028
    9. resequenced IMPDH1 and IMPDH2 using DNA from 288 individuals from three ethnic groups and performed functional genomic studies of the sequence variants observed; identified 73 single nucleotide polymorphisms in IMPDH1, 59 novel PMID: 20718729
    10. Potential associations between the most frequent single nucleotide polymorphisms in both IMPDH genes and clinical outcome in renal transplant recipients. PMID: 20679962
    11. Inosine 5'-monophosphate dehydrogenase 1 haplotypes have a role in mycophenolate mofetil gastrointestinal intolerance in pediatric heart transplant patients PMID: 20649757
    12. The risk of subclinical acute rejection for recipients who cannot adapt in therapeutic drug monitoring of mycophenolic acid seems to be influenced by IMPDH1 rs2278293 polymorphism. PMID: 20136638
    13. In this small sample of pediatric heart transplant patients receiving MMF, ABCC2, IMPDH1 and IMPDH2 SNPs were associated with MMF GI intolerance and bone marrow toxicity. PMID: 20061166
    14. This mutant isoenzyme maps to human chromosome region 7q and has an amino acid substitution (arginine for proline). It is involved in the etiology of autosomal dominant retinitis pigmentosa in humans. PMID: 11875049
    15. A missense mutation in this isozyme causes human autosomal retinitis pigmentosa. PMID: 11875050
    16. A novel IMPDH1 gene mutation (Arg231Pro) was associated with a severe form of autosomal dominant retinitis pigmentosa. PMID: 15465556
    17. The most commonly reported Asp226Asn mutation was not found in the Japanese population, instead two novel mutations were found. These findings suggest that mutations of the IMPDH1 gene cause ADRP (autosomal dominant retinitis pigmentosa). PMID: 16038673
    18. Asp226Asn mutation is associated with a severe, early-onset form of retinal degeneration in members of this family. PMID: 16214101
    19. In this family with a mutation in IMPDH1, we found a specific phenotype with rod function affected more than cone function, foveal edema, and central retinal function preserved for a long period of time. PMID: 16272056
    20. Mutations in IMPDH1 account for approximately 2% of families with adRP, and de novo IMPDH1 mutations are also rare causes of isolated LCA (Leber congenital amaurosis). PMID: 16384941
    21. Identification of unique retinal isoforms supports the existence of a novel IMPDH1 function in the retina, one that is probably altered by disease-causing mutations. PMID: 16936083
    22. If IMPDH genetic variability contributes to azathioprine resistance in inflammatory bowel disease it does so infrequently. PMID: 17001353
    23. Mycophenolate mofetil up-regulates IMPDH-I and IMPDH-II mRNA in peripheral blood mononuclear cells. May predict acute rejection. PMID: 17713475
    24. C-terminal extension unique to the retinal isoforms blocks the nucleic acid binding site of IMPDH1, and thus uniquely regulates protein function within photoreceptors. PMID: 18295591
    25. RHO, PRPF31, RP1, and IMPDH1 were screened and causative mutations were identifiedin 4% of isolated and 2% of autosomal dominant forms of retinitis pigmentosa patients from India. PMID: 18552984
    26. IMP dehydrogenase type 1 associates with polyribosomes translating rhodopsin mRNA PMID: 18974094

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  • 相关疾病：
    Retinitis pigmentosa 10 (RP10); Leber congenital amaurosis 11 (LCA11)
  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    IMPDH/GMPR family
  • 组织特异性：
    IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor.
  • 数据库链接：

    HGNC: 6052

    OMIM: 146690

    KEGG: hsa:3614

    STRING: 9606.ENSP00000345096

    UniGene: Hs.654401