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INPP4A Antibody

  • 货号：
    CSB-PA853479ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: INPP4A antibody at 8.79 μg/ml + Mouse brain tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 110, 106, 108 kDa
      Observed band size: 110, 48 kDa
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA853479ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) INPP4A Polyclonal antibody
  • Uniprot No.：
    Q96PE3
  • 基因名：
  • 别名：
    107kDa antibody; 4-bisphosphate 4-phosphatase antibody; 9630012D15 antibody; D130048C09Rik antibody; Inositol polyphosphate 4 phosphatase type I 107kDa antibody; Inositol polyphosphate 4 phosphatase type I antibody; Inositol polyphosphate 4-phosphatase type I antibody; INP4A_HUMAN antibody; INPP4 antibody; Inpp4a antibody; OTTHUMP00000203138 antibody; OTTHUMP00000203139 antibody; OTTHUMP00000203141 antibody; OTTHUMP00000225217 antibody; R74740 antibody; TVAS1 antibody; Type I inositol 3 4 bisphosphate 4 phosphatase antibody; Type I inositol 3,4 bisphosphate 4 phosphatase antibody; Type I inositol-3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Type I inositol 3,4-bisphosphate 4-phosphatase protein (1-250AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2). Catalyzes also inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. May protect neurons from excitotoxic cell death by regulating the synaptic localization of cell surface N-methyl-D-aspartate-type glutamate receptors (NMDARs) and NMDAR-mediated excitatory postsynaptic current.; Displays no 4-phosphatase activity for PtdIns(3,4)P2, Ins(3,4)P2, or Ins(1,3,4)P3.
  • 基因功能参考文献：
    1. Our findings indicate that upregulation of miR-935 may promote pancreatic cancer cell proliferation and migration and inhibit cell apoptosis by targeting INPP4A. PMID: 27733216
    2. INPP4A could possibly serve as a candidate gene for alterations associated with asbestos exposure. PMID: 26463840
    3. Data adds a new etiology to the spectrum of hindbrain malformations in human, and when presented with myoclonic epilepsy may lead to the clinical suspicion of INPP4A defect. PMID: 25338135
    4. INPP4A represents the first signalling protein with a function in neurons to suppress excitotoxic cell death PMID: 20463662
    5. in quiescent cells, the 4-phosphatase colocalized with early and recycling endosomes PMID: 15716355
    6. The +110832A/G (Thr/Ala) variant of INPP4A was significantly associated with asthma in an Indian population. PMID: 18187694

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  • 亚细胞定位：
    Early endosome membrane. Recycling endosome membrane. Cell membrane. Nucleus. Cytoplasm. Cell junction, synapse, postsynaptic density.
  • 蛋白家族：
    Inositol 3,4-bisphosphate 4-phosphatase family
  • 组织特异性：
    Isoform 1 is expressed in the platelets, MEG-01 megakaryocytes and Jurkat T-cells. Isoform 2 is expressed in the brain.
  • 数据库链接：

    HGNC: 6074

    OMIM: 600916

    KEGG: hsa:3631

    STRING: 9606.ENSP00000074304

    UniGene: Hs.469386