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INTS3 Antibody

  • 货号：
    CSB-PA011761LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of Hela cells with CSB-PA011761LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) INTS3 Polyclonal antibody
  • Uniprot No.：
    Q68E01
  • 基因名：
    INTS3
  • 别名：
    INTS3 antibody; C1orf193 antibody; C1orf60 antibody; Integrator complex subunit 3 antibody; Int3 antibody; SOSS complex subunit A antibody; Sensor of single-strand DNA complex subunit A antibody; SOSS-A antibody; Sensor of ssDNA subunit A antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Integrator complex subunit 3 protein (901-1043AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，INTS3 Antibody (CSB-PA011761LA01HU)，的标记方式是Non-conjugated。对于INTS3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA011761LB01HU INTS3 Antibody, HRP conjugated ELISA
    FITC CSB-PA011761LC01HU INTS3 Antibody, FITC conjugated
    Biotin CSB-PA011761LD01HU INTS3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the Integrator (INT) complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex.; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites.
  • 基因功能参考文献：
    1. In response to the DNA damage response, INTS3-hSSB1-INTS6 complex relocates to the DNA damage sites. PMID: 23986477
    2. INTS3 is part of an ssDNA-binding heterotrimeric complex, SOSS which is involved in the maintenance of genome stability. PMID: 19683501
    3. INT3 plays a key role in the DNA damage response PMID: 19759019
    4. INTS3 controls the hSSB1-mediated DNA damage response. PMID: 19786574
  • 亚细胞定位：
    Nucleus. Cytoplasm. Note=Localizes to nuclear foci following DNA damage.
  • 蛋白家族：
    Integrator subunit 3 family
  • 数据库链接：

    HGNC: 26153

    OMIM: 611347

    KEGG: hsa:65123

    STRING: 9606.ENSP00000318641

    UniGene: Hs.438723