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IPPK Antibody

  • 货号：
    CSB-PA011783GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9H8X2
  • 基因名：
  • 别名：
    3 antibody; 4 antibody; 5 antibody; 6)P5 2-kinase antibody; 6-pentakisphosphate 2-kinase antibody; bA476B13.1 (novel protein) antibody; bA476B13.1 antibody; C9orf12 antibody; inositol 1,3,4,5,6 pentakisphosphate 2 kinase antibody; Inositol pentakisphosphate 2 kinase antibody; Inositol-1 antibody; Inositol-pentakisphosphate 2-kinase antibody; Ins antibody; Ins(1 antibody; Ins(1,3,4,5,6)P5 2 kinase antibody; InsP5 2 kinase antibody; InsP5 2-kinase antibody; INSP5K2 antibody; IP5K antibody; IPK1 antibody; IPK1 homolog antibody; IPPK antibody; IPPK_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human IPPK
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis.
  • 基因功能参考文献：
    1. These results imply that DBP5, GLE1 and IP6 have a conserved and individual function in the cytoplasmic mRNA expression. Variations in phenotype are due to the difference in each function of DBP5, GLE1 and IPPK in intracellular mRNA metabolism. PMID: 29746542
    2. IP6 synthase, Ins(1,3,4,5,6)P5 2-kinase (IPPK/IP5K) binds to cullins. Depleting IP5K increases the percentage of neddylated, active Cul1 and Cul4A, and decreases levels of the Cul1/4A substrates p27 and p21. PMID: 26976604
    3. IPK1 substrate selection is linked to the ability of each potential substrate to stabilize IPK1. PMID: 24165122
    4. identified a genomic DNA sequence on chromosome 9 that encodes inositol 1,3,4,5,6-pentakisphosphate 2-kinase; characterization of the enzyme PMID: 12084730
  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    IPK1 type 2 family
  • 组织特异性：
    Ubiquitously expressed, with high expression in heart, brain, testis and placenta.
  • 数据库链接：

    HGNC: 14645

    KEGG: hsa:64768

    STRING: 9606.ENSP00000287996

    UniGene: Hs.459896