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IQGAP2 Antibody

  • 货号：
    CSB-PA615701LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA615701LA01HU diluted at 1:500 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of HepG2 cells with CSB-PA615701LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) IQGAP2 Polyclonal antibody
  • Uniprot No.：
    Q13576
  • 基因名：
  • 别名：
    IQ motif containing GTPase activating protein 2 antibody; IQGA2_HUMAN antibody; Iqgap2 antibody; Ras GTPase activating-like protein antibody; Ras GTPase-activating-like protein IQGAP2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Ras GTPase-activating-like protein IQGAP2 protein (1245-1395AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，IQGAP2 Antibody (CSB-PA615701LA01HU)，的标记方式是Non-conjugated。对于IQGAP2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA615701LB01HU IQGAP2 Antibody, HRP conjugated ELISA
    FITC CSB-PA615701LC01HU IQGAP2 Antibody, FITC conjugated
    Biotin CSB-PA615701LD01HU IQGAP2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:500-1:1000
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.
  • 基因功能参考文献：
    1. IQGAP2 expression correlated positively with survivability, on the contrary, IQGAP3 expression levels correlated inversely with survivability PMID: 29073199
    2. The structural basis for Cdc42-induced dimerization of IQGAP1 and IQGAP2 has been uncovered. PMID: 27524202
    3. The most frequently identified and connected to preterm birth genes in the exome library were IGF1, ATM and IQGAP2. PMID: 27163930
    4. IQGAP2 TagSNP rs457717 (A/G) was not associated with Age-Related Hearing impairment in Han male Chinese population. PMID: 26187738
    5. Thus, these data identified IQGAP2 as a novel tumor suppressor for ovarian cancer to inhibit cell invasion through regulating Wnt/b-catenin signaling, and provided a new biomarker and potential therapeutic strategy for this disease. PMID: 26549344
    6. we identified IQGAP2 as a human and zebrafish podocyte gene product that is downregulated in microarray data sets from kidney biopsies of human patients with focal segmental glomerulosclerosis and minimal change nephrotic syndrome. PMID: 26154927
    7. Data show that IQ motif-containing GTPase-activating protein 2 (IQGAP2) expression is altered in colitis. PMID: 26047140
    8. IQGAP1, IQGAP2, and IQGAP3 have diverse roles in vertebrate physiology, operating in the kidney, nervous system, cardiovascular system, pancreas, and lung. (Review) PMID: 25722290
    9. Mammalian IQGAP proteins may play a role in cytokinesis by regulating the localization of key cytokinesis regulatory proteins to the contractile apparatus during mitosis. PMID: 25229330
    10. Low IQGAP2 expression was associated with hepatocellular carcinoma. PMID: 24998570
    11. The first IQ-motifs from IQGAP2 and IQGAP3 form transient interactions with calmodulin in the absence of calcium. PMID: 21299499
    12. observations strongly indicate that IQGAP2 is a surveillance type of tumour suppressor for prostate cancer PMID: 22406297
    13. increased IQGAP1 and/or decreased IQGAP2 contribute to the pathogenesis of human HCC. PMID: 20977743
    14. The top-ranked SNP, rs457717 for association with age-related hearing impairment(P-value 3.55 x 10(-7)), was localised in an intron of the IQ motif-containing GTPase-activating-like protein (IQGAP2). PMID: 20068591
    15. The gene for the putative rac1/cdc42 effector protein IQGAP2 was found in the PAR gene cluster at 5q13, flanked by PAR1 & encompassing PAR3. It functions as a GTP-dependent effector protein in thrombin-induced platelet cytoskeletal reorganization. PMID: 12515716
    16. silencing of IQGAP2 by promoter methylation may contribute to gastric cancer development. PMID: 17957782

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  • 组织特异性：
    Isoform 2 expression is enhanced in testis.
  • 数据库链接：

    HGNC: 6111

    OMIM: 605401

    KEGG: hsa:10788

    STRING: 9606.ENSP00000274364

    UniGene: Hs.291030