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  4. IRF8 Antibody

IRF8 Antibody

  • 货号：
    CSB-PA011823ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human epityphlon tissue using CSB-PA011823ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) IRF8 Polyclonal antibody
  • Uniprot No.：
    Q02556
  • 基因名：
  • 别名：
    H ICSBP antibody; H-ICSBP antibody; HGNC:5358 antibody; HICSBP antibody; ICSBP 1 antibody; ICSBP antibody; ICSBP1 antibody; Interferon consensus sequence binding protein 1 antibody; Interferon consensus sequence binding protein antibody; Interferon consensus sequence-binding protein antibody; Interferon regulatory factor 8 antibody; IRF 8 antibody; IRF-8 antibody; Irf8 antibody; IRF8_HUMAN antibody; MYLS antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Interferon regulatory factor 8 protein (137-426AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcription factor that specifically binds to the upstream regulatory region of type I interferon (IFN) and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Can both act as a transcriptional activator or repressor. Plays a negative regulatory role in cells of the immune system. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes. Required for the development of plasmacytoid dendritic cells (pDCs), which produce most of the type I IFN in response to viral infection. Positively regulates macroautophagy in dendritic cells.
  • 基因功能参考文献：
    1. Exogenous expression of IRF8 in the silenced or downregulated lung cancer cell lines restored the sensitivity of lung cancer cells to apoptosis, and arrested cells at the G0/G1 phase. IRF8 bound to the T-cell factor/lymphoid enhancer factor (TCF /LEF) promoter, thus repressing beta-catenin nuclear translocation and its activation. PMID: 30466106
    2. Study shows that hypermethylation of IRF8 associated with decreased mRNA expression in dendritic cells confers risk to VKH disease. PMID: 28432342
    3. IRF8 upregulation in tumor cells inhibited the generation of Th17 cells in vitro, and this may be mediated by the downregulation of RORgammat. we found that a high level of IRF8 in the DLBCL tumor microenvironment was a predictor of poor survival in DLBCL patients. PMID: 28537908
    4. These findings identify IRF8 as a novel tumor suppressor regulating IFN-gamma/STAT1 signaling and beta-catenin signaling in breast cancer. PMID: 28388578
    5. Irf8 induction, but not its knockdown, decreased APL leukemogenic potential through driving monocytic maturation. PMID: 28492552
    6. Total cellular protein presence of the transcription factor IRF8 does not necessarily correlate with its nuclear presence. PMID: 27582125
    7. IRF8 is dispensable for induced pluripotent stem cell and embryonic stem cell differentiation into hemogenic endothelium and for endothelial-to-hematopoietic transition. PMID: 28090699
    8. TP(thymidine phosphorylase ) curbed the expression of three proteins-IRF8, RUNX2, and osterix. This downregulation was epigenetically driven: High levels of 2DDR, a product of TP secreted by myeloma cells, activated PI3K/AKT signaling and increased the methyltransferase DNMT3A's expression PMID: 27658717
    9. It findings provide evidence for an additional mechanism of epigenetic IRF8 silencing during osteoclastogenesis that likely works cooperatively with DNA methylation, further emphasizing the importance of IRF8 as a negative regulator of osteoclastogenesis. PMID: 27183582
    10. Data suggest that ubiquitin specific protease 4 (USP4) interacts with interferon regulatory factor 8 (IRF8) and, by its Lys48-specific deubiquitinase/endopeptidase activity, stabilizes IRF8 protein levels in regulatory T-lymphocytes; USP4 and IRF8 are also expressed in helper T-lymphocytes. PMID: 28477415
    11. these data indicate that human NK cells require IRF8 for development and functional maturation and that dysregulation of this function results in severe human disease, thereby emphasizing a critical role for NK cells in human antiviral defense. PMID: 27893462
    12. down-regulation of IRF8 in the wound leads to impaired wound healing possibly through the regulation of macrophage function and apoptosis in skin wound. PMID: 27709315
    13. IRF8 may contribute to the genetic susceptibility of Behcet's disease by regulating IRF8 expression and cytokine production. PMID: 26794091
    14. IRF5 and IRF8, two transcription factors with opposing functions, control TLR9 signaling in human plasmacytoid dendritic cells. PMID: 26613957
    15. cytarabine-induced upregulation of the IRF8 in leukemic cells involves increased levels of ZNF224, which can counteract the repressive activity of WT1 on the IRF8-promoter PMID: 26563595
    16. Expression of WT1and IRF8 showed a moderate inverse correlation in acute myeloid leukemia patients. WT1 can be used as an minimal residual disease marker, especially in patients without recurrent genetic abnormalities. PMID: 25387409
    17. Results show that IRF8 is a possible genetic variant associated with the development of HT and production of thyroid antibody PMID: 25989711
    18. The IRF8 gene variant influenced the interaction between IRF8 and NF-kappaB and thus susceptibility to systemic sclerosis. PMID: 25880423
    19. This article provides an overview of recent advances in our understanding of the role of IRF8 in myelopoiesis and related diseases. [review] PMID: 25749660
    20. This study demonstrated that the Polymorphism, Single Nucleotide of IRF8 is associated with multiple sclerosis in woman in Russia. PMID: 25903733
    21. gene variants in IRF5, IRF8 and GPC5 were not associated with risk of relapse or disease progression in multiple sclerosis PMID: 24943672
    22. Irf8 forms a negative feedback loop with Cebpb, a monocyte-derived DC epigenetic fate-determining transcription factor. PMID: 25453760
    23. MN1 prevents activation of the immune response pathway, and suggest restoration of IRF8 signaling as therapeutic target in AML PMID: 24957708
    24. Data demonstrate that IRF8 as a functional tumor suppressor is frequently methylated in RCC, and IRF8-mediated interferon signaling is involved in RCC pathogenesis. PMID: 25109451
    25. The IRF8 gene polymorphisms might be associated with susceptibility to SLE. PMID: 24034601
    26. Data demonstrate a novel function for ICSBP in epithelial-mesenchymal transition, cell motility, and invasion through the TGF-beta and Snail signaling pathways. PMID: 24832596
    27. These data reveal a previously unrecognized BCR-ABL-STAT5-IRF-8 network, which widens the repertoire of potentially new anti-chronic myeloid leukemia targets. PMID: 24753251
    28. IRF8 is associated with germinal center B-cell-like type of diffuse large B-cell lymphoma and exceptionally involved in translocation t(14;16)(q32.33;q24.1). PMID: 23573829
    29. Mutations in linker histone genes HIST1H1 B, C, D, and E; OCT2 (POU2F2); IRF8; and ARID1A underlying the pathogenesis of follicular lymphoma. PMID: 24435047
    30. the prognostic significance of IRF8 transcripts in other populations of AML patients PMID: 23967110
    31. In a Korean population, there was no association of IRF8 polymorphisms, with inflammatory demyelinating diseases. PMID: 22994200
    32. novel insights into the contribution of EBNA3C to EBV-mediated B-cell transformation through regulation of IRF4 and IRF8 and add another molecular link to the mechanisms by which EBV dysregulates cellular activities PMID: 23658517
    33. Using a capture sequencing strategy, we discovered the B-cell relevant genes IRF8, EBF1, and TNFSF13 as novel targets for IGH deregulation. PMID: 23775715
    34. Coronary heart disease in systemic lupus erythematosus is associated with IRF8 gene variants. PMID: 23661672
    35. A 3'UTR variant in IRF8 gene is associated with risk of chronic lymphocytic leukemia. PMID: 23307532
    36. these results underscore a key role of IRF-8 in the cross talk between melanoma and immune cells, thus revealing its critical function within the tumor microenvironment in regulating melanoma progression and invasiveness. PMID: 23308054
    37. IRF8 is required for ontogeny of the myeloid lineage and for host response to mycobacteria. The K108E & T80A mustations cause distinct forms of a novel primary immunodeficiency & associated susceptibility to mycobacteria. Review. PMID: 23468103
    38. The association of IRF1 and IRF8 variants with tuberculosis susceptibility was investigated. PMID: 22879909
    39. In resting macrophages, some IRF8 is conjugated to small ubiquitin-like modifiers (SUMO) 2/3 through the lysine residue 310. Macrophage activation prompts a reduction in SUMOylated IRF8. PMID: 22942423
    40. Four additional susceptibility loci (IRF8, TMEM39A, IKZF3, and ZPBP2) for systemic lupus erythematosus were robustly established a multiethnic population (European, African American, Asian, Hispanic, Gullah, and Amerindian). PMID: 22464253
    41. interaction between Tel and Tel-PdgfRbeta decreases Tel/Icsbp/Hdac3 binding to the PTPN13 cis element, resulting in increased transcription. PMID: 22262849
    42. Data showed that IRF8 target genes contributes to multiple aspects of the biology of mature B cells including critical components of the molecular crosstalk among GC B cells, T follicular helper cells, and follicular dendritic cells. PMID: 22096565
    43. Association analysis identified five SLE susceptibility genes reaching genome-wide levels of significance : NCF2 ,IKZF1 ,IRF8 ,IFIH1 , and TYK2 PMID: 22046141
    44. IRF4 has activities similar to IRF8 in regulating myeloid cell development PMID: 22003407
    45. [review] Induction of transcriptional repressors such as IRF8 is one of the mechanisms that inhibits osteoclastogenesis. PMID: 22082370
    46. study identifies a novel role for ICSBP in regulating cell growth via TGF-beta receptor upregulation and subsequent activation of the TGF-beta receptor/TAK-1/p38 pathway PMID: 21625229
    47. The promoter was methylated in many MDS or AML patients. This may be the main mechanism of ICSBP inactivation in myeloid malignancies & may be functionally important for accumulation of chromosome aberrations during leukemic progression. PMID: 21475251
    48. association of single nucleotide polymorphisms to multiple sclerosis PMID: 21552549
    49. We detected two distinct disease-causing mutations affecting interferon regulatory factor 8 (IRF8). Both mutations impair IRF8 transcriptional activity. PMID: 21524210
    50. Findings determine the mechanism of IRF8 downregulation in CML cells. PMID: 21487040

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  • 相关疾病：
    Immunodeficiency 32A (IMD32A); Immunodeficiency 32B (IMD32B)
  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    IRF family
  • 组织特异性：
    Predominantly expressed in lymphoid tissues.
  • 数据库链接：

    HGNC: 5358

    OMIM: 601565

    KEGG: hsa:3394

    STRING: 9606.ENSP00000268638

    UniGene: Hs.137427