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  4. IRS2 Antibody

IRS2 Antibody

  • 货号：
    CSB-PA036177
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA036177(IRS2 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA036177(IRS2 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y4H2
  • 基因名：
  • 别名：
    Insulin receptor substrate 2 antibody; IRS 2 antibody; IRS-2 antibody; Irs2 antibody; IRS2_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human IRS2
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May mediate the control of various cellular processes by insulin.
  • 基因功能参考文献：
    1. Study suggests that polymorphisms of IRS2 putatively participated in the development of pediatric MB development. PMID: 28303061
    2. Urinary sediment cell expression of IRS2 gene was significantly increased in the diabetic nephropathy (DN) patients compared with other groups. In patients with DN, urinary mRNA expression of the IRS2 gene is associated with kidney function. PMID: 29891743
    3. Insulin signaling pathway protects neuronal cell lines by Sirt3 mediated IRS2 activation. PMID: 29411439
    4. Acute loss of IRS1/IRS2 or inhibition of IR/IGF1R in KRAS-mutant human NSCLC cells decreases the uptake and lowers the intracellular levels of amino acids, while enhancing basal autophagy and sensitivity to autophagy and proteasome inhibitors. PMID: 29610318
    5. that MTNR1B and IRS2 gene variants impacted epicardial fat thickness, lipid profile and glucose homeostasis PMID: 28708046
    6. this meta-analysis indicates that IRS-2 gene rs1805097 polymorphism decreased the risk of CRC. PMID: 28212577
    7. IRS-1 and IRS-2 signaling interaction with the microtubule cytoskeleton and its response to AKT determines the response to microtubule disruption in breast carcinoma cells PMID: 28320862
    8. The study results were suggestive of a positive association between Gly972Arg of IRS1 and PCOS in the south Indian population, while INS, IRS2, PPAR-G and CAPN10 failed to show any association with PCOS in our studied population. PMID: 28360393
    9. We concluded that USP15 attenuates IGF-I signaling by antagonizing Nedd4-induced IRS-2 ubiquitination. PMID: 28126338
    10. these data highlight two novel regulatory proteins that could be therapeutically manipulated to limit IL-4-induced IRS-2 signaling and polarization of M2 macrophages in allergic inflammation. PMID: 27742835
    11. Proteasomal inhibition prolonged IRS-2 tyrosine phosphorylation, increased ubiquitination of IRS-2, and enhanced M2 gene expression. PMID: 27507812
    12. Findings suggest that insulin receptor substrate -1 Gly972Arg polymorphism is associated with polycystic ovary syndrome in the Caucasian ethnicity, and insulin receptor substrate -2 Gly1057Asp polymorphism is correlated with polycystic ovary syndrome in the Asian ethnicity. However, insulin receptor His 1058 C/T polymorphism may not be implicated in polycystic ovary syndrome. PMID: 27098445
    13. In the renal proximal tubule, insulin signaling via IRS1 is inhibited, while insulin signaling via IRS2 is preserved. Insulin signaling via IRS2 continues to stimulate sodium reabsorption in the proximal tubule and causes sodium retention, edema, and hypertension. PMID: 27247938
    14. miRNA-146a may function as a useful clinical tool in the treatment and diagnosis of ESCC, and its overexpression suppressed cell growth through inhibition of IRS2. PMID: 26508028
    15. High IRS2 expression is associated with myeloproliferative neoplasms. PMID: 26755644
    16. FSH decreases IRS-2 mRNA degradation indicating post-transcriptional stabilization. PMID: 26388164
    17. These data demonstrate for the first time that miR146a suppresses lung cancer progression by repressing IRS2 expression PMID: 26238771
    18. IRS-specific gene signatures represent accurate surrogates of IGF activity and could predict response to anti-IGF therapy in breast cancer. PMID: 26991655
    19. These results indicate that miR-106a* affects renal cell carcinoma (RCC) progression by targeting IRS-2 with suppression of the PI3K/Akt signaling pathway in RCC cells PMID: 26018509
    20. meta-analysis of genetic association studies: Data suggest that the D allele of the G1057D SNP in IRS2 has a significant effect on reducing risk of type 2 diabetes mellitus; obesity is a modifier of this association. [META-ANALYSIS, REVIEW] PMID: 25959789
    21. We conclude that AFB1 may upregulate IRS2 and stimulate lung cancer cell migration through Src PMID: 25820822
    22. IRS2 copy number gain, IGF-1R, IR-A, and IGFBP6 RNA expression levels, and KRAS and BRAF mutational status were identified as candidate predictive biomarkers for response to BMS-754807. PMID: 25527633
    23. Results suggest that a genetic variation in the insulin signaling pathway genes IRS1, IRS2 and INSR may affect the therapeutic response of temporal lobe epilepsy PMID: 25458098
    24. Study found significant association of the variant of IRS-2 gene as well as the interaction of IRS-1 and IRS-2 genes with polycystic ovary syndrome, especially in non-obese women from Taiwan. PMID: 25310961
    25. IRS2 phosphorylation is cell cycle-regulated and that Plk1 phosphorylation of IRS2 prevents premature mitotic exit via AKT inactivation. PMID: 25830382
    26. Changes in the expression levels of IRS1, IRS2, RIPK2, RSPO1, and DNA JC15 genes might contribute to the development of insulin resistance and glucose intolerance in the obese boys. PMID: 26040030
    27. Data (including data from knockout mice) suggest reduced insulin/IGF1 (insulin-like growth factor I) signaling slows progressive neurodegeneration of aging and increases life span via mechanism involving IRS2. [REVIEW] PMID: 25200290
    28. Increased expression of IRS2 is associated with oral squamous cell carcinoma. PMID: 24810113
    29. simulation shows that the wiring of the network determines different functions of IRS1 and IRS2. PMID: 24703981
    30. IGF-2, IGF-2R, and IRS-2 genes polymorphisms and their combinations are associated with risk of HCC PMID: 24656929
    31. IRS2 (rs2289046) GG genotype compared with AA+AG genotypes has a protective effect for colorectal cancer in normal weight subjects. PMID: 24175768
    32. The IRS2 rs1805097 polymorphism is not associated with colorectal and breast cancer risk. [Meta-analysis] PMID: 24497996
    33. Hepatitis C virus infection triggers endoplasmic reticulum stress and downregulates IRS1 and IRS2 through upregulation of SOCS-3. PMID: 25283858
    34. These results suggest that IRS-2 1057D allele may be associated with gestational diabetes mellitus. PMID: 24401133
    35. IRS1/2 promotes EMT and cell proliferation through stabilizing Dvl2. PMID: 24616100
    36. Differential regulation of IRS1 and IRS2 and of their downstream effectors AKT1 and AKT2 is consistent with upregulation of FOXO1 PMID: 23147115
    37. This study showed that three examined SNPs (rs2059806, Ala550Ala in INSR; rs1801123, Ala804Ala in IRS1; rs4773092, Cys816Cys, IRS2) did not show association with schizophrenia. PMID: 23706954
    38. Upregulation of IRS2 in the kidney tubules of diabetic nephropathy (DN) patients also indicates a novel role for IRS2 as a marker and/or mediator of human DN progression. PMID: 23617393
    39. IRS-2 Gly1057Asp polymorphisms are associated with T2DM in the Kurdish ethnic group. PMID: 22994406
    40. These data identify IRS2 as a likely driver oncogene in the prevalent 13q34 region of gain/amplification and suggest that IRS2 over-expression may provide an additional mechanism of PI3 kinase pathway activation in colorectal cancer. PMID: 23594372
    41. IRS-1 to IRS-2 ratios were lower in malignant than in benign prostatic tissue PMID: 23251408
    42. CaMK4 regulates beta-cell proliferation and apoptosis in a CREB-dependent manner and CaMK4-induced IRS-2 expression is important in these processes PMID: 23049845
    43. Amino acids 300-600 of IRS-2 are the 14-3-3 binding region with an important role for IGF-1/insulin-regulated phosphorylation of Ser-573. PMID: 22912850
    44. in elderly subjects the presence of the allelic variant Gly1057Asp of IRS2 gene was associated with the degree of insulin resistance and with epicardial fat thickness, suggesting its contribution to global cardiometabolic risk. PMID: 23018177
    45. Gly allele at codon 1057 in IRS-2 is correlated with an increased susceptibility to coronary artery disease in the Taiwanese population PMID: 23216712
    46. No significant associations were observed in IRS-2 Gly1057Asp polymorphism with polycystic ovary syndrome. PMID: 22523112
    47. CASP3 rs4862396, BMP5 rs3734444 and IRS2 rs7986346 may affect the survival in patients after androgen-deprivation therapy for prostate cancer PMID: 22844442
    48. no association between the IRS-1 and IRS-2 polymorphisms and Polycystic ovary syndrome were found. The results confirm that these polymorphisms should not be considered as major contributors to the pathogenesis of this disorder PMID: 22205343
    49. Defective IRS2 expression plays a role in the impaired hematopoietic cell differentiation in myelodysplastic syndrome. PMID: 22465474
    50. The rs2289046 polymorphism at the IRS2 gene locus may influence insulin sensitivity by interacting with certain plasma fatty acids in in metabolic syndrome subjects. PMID: 22147666

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  • 亚细胞定位：
    Cytoplasm, cytosol.
  • 数据库链接：

    HGNC: 6126

    OMIM: 600797

    KEGG: hsa:8660

    STRING: 9606.ENSP00000365016

    UniGene: Hs.442344