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IRX2 Antibody

  • 货号：
    CSB-PA003070
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HepG2 cells using IRX2 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q9BZI1
  • 基因名：
    IRX2
  • 别名：
    Homeodomain protein IRXA2 antibody; Iroquois homeobox 2 antibody; Iroquois homeobox protein 2 antibody; Iroquois-class homeodomain protein irx-2 antibody; IRX 2 antibody; irx2 antibody; IRX2_HUMAN antibody; IrxA2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human IRX2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 基因功能参考文献：
    1. IRX2 transcription factor might represent a novel metastasis associated protein that acts as a negative regulator of cellular motility and as a repressor of chemokine expression and loss of IRX2 expression could therefore contribute to early hematogenous dissemination of breast cancer by sustaining chemokine secretion and enabling mobilization of tumor cells. PMID: 26560478
    2. IRX2 modulates the expression levels of MMP2 and VEGF in an AKTdependent manner. PMID: 26062523
    3. The mechanism by which IRX2 promoted cell proliferation and invasion by activating AKT and MMP9 was detected. PMID: 24806332
    4. Results revealed 3 genes highly predictive of event-free survival (EFS), beyond age and MLL status: FLT3, IRX2, and TACC2. PMID: 22210879
    5. IRX2 represents a candidate target of 5p amplifications in soft tissue sarcomas and might play a crucial role during the progression of this disease. PMID: 16752383

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    TALE/IRO homeobox family
  • 数据库链接：

    HGNC: 14359

    OMIM: 606198

    KEGG: hsa:153572

    STRING: 9606.ENSP00000307006

    UniGene: Hs.282089