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ITGAX Antibody

  • 货号：
    CSB-PA843535
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using CSB-PA843535(ITGAX Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    P20702
  • 基因名：
  • 别名：
    95 alpha chain antibody; 95 antibody; CD 11c antibody; CD11 antigen like family member C antibody; CD11 antigen-like family member C antibody; CD11c antibody; CD11c antigen antibody; Complement component 3 receptor 4 subunit antibody; CR4 antibody; Integrin alpha X antibody; Integrin alpha X chain antibody; Integrin alpha-X antibody; Integrin aX antibody; Integrin subunit alpha X antibody; integrin, alpha X (antigen CD11C (p150), alpha polypeptide) antibody; integrin, alpha X (complement component 3 receptor 4 subunit antibody; ITAX_HUMAN antibody; ITGAX antibody; LEU M5 alpha subunit antibody; Leu M5 antibody; Leukocyte adhesion glycoprotein p150 95 alpha chain antibody; Leukocyte adhesion glycoprotein p150 antibody; Leukocyte adhesion receptor p150 95 antibody; Leukocyte adhesion receptor p150 antibody; Leukocyte surface antigen p150 95 alpha subunit antibody; Leukocyte surface antigen p150 alpha subunit antibody; Myeloid membrane antigen alpha subunit antibody; p150 95 integrin alpha chain antibody; p150 antibody; p150/95 antibody; SLEB6 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human ITGAX
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:15-1:50
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.
  • 基因功能参考文献：
    1. This study provides evidence that CD11c is involved in the susceptibility to Behcet's disease in a Chinese Han population. PMID: 27108704
    2. The main mechanism of Integrin alphaXbeta2 I-domain binding to RAGE is a charge interaction, in which the acidic moieties of Integrin alphaXbeta2 I-domains, including E244, and D249, recognize the basic residues on the RAGE V-domain encompassing K39, K43, K44, R104, and K107. PMID: 28535664
    3. Studies indicate that CD11c+ T-bet+ memory B cells exhibit a distinct transcriptome. PMID: 28838763
    4. Studies indicate enriched expression of TBX21 (T-bet), which is important for B cell survival and response to antigen, was observed in CD11c+ B cells. PMID: 28756897
    5. CD11c, expressed not only in Hairy cell leukemia but also in dendritic cells, macrophages and monocytes is a differentiation marker for inflammation. Prolonged inflammation in the microenvironment of CLL cells may cause a susceptibility to autoimmune disorders and secondary tumors in CLL, in this way, an increase in mortality. PMID: 28603911
    6. We can achieve possible clinical significance of lymphoma tumor microenvironments through CD11c and FOXP3 immunohistochemistry stains in extranodal diffuse large B-cell lymphoma patients receiving R-CHOP therapy. PMID: 26968188
    7. Circulating CD11c+ T cells were associated with the expression of multiple adhesion molecules in women, suggesting that these cells have high tissue homing potential. These data suggest that CD11c expression distinguishes a population of circulating T cells during bacterial infection with innate capacity and mucosal homing potential. PMID: 27119555
    8. CD8+ T cells of Behcet's disease patients exhibited increased CD11c expression levels, which may contribute to disease pathogenesis. PMID: 27309860
    9. High expression of CD11c decreased the risk of death and relapse, and may be regarded as an alternative indicator of favorable prognosis in patients with gastric cancer. PMID: 26309367
    10. the CD11c molecule possesses four different cellular patterns in the periprosthetic tissues. PMID: 26255872
    11. Data show that the percentage of CD11c positive antigen presenting cells (CD11c(+) APCs) in the peripheral blood of active pulmonary tuberculosis (APT) patients was much higher than that in the controls. PMID: 26927560
    12. Data suggest that blood neutrophils expressing CD11c antigen and EMR2 protein be considered as potential biomarkers for sepsis and systemic inflammatory response syndrome (SIRS), respectively. PMID: 26153037
    13. three of these five genes (CXCL14, ITGAX, and LPCAT2) harbored polymorphisms associated with aggressive disease development in a human GWAS cohort consisting of 1,172 prostate cancer patients. PMID: 25411967
    14. infiltration of MBP(+) and CD11c(+) innate immune cells show a significant association with phenotype and disease extent of non-asthmatic chronic rhinosinusitis PMID: 25361058
    15. the phosphorylation site of CD11c as Ser-1158 is pivotal for adherence and phagocytosis. PMID: 24129562
    16. Chronic myelomonocytic leukemia monocytes uniformly display a population of monocytes with CD11c underexpression. PMID: 24124148
    17. Data indicate that the frequencies of CD11c, CD11c/CD86, HLA-DR/CD86, CD83 and CD80 were significantly high, while CD11c/HLA-DR was low in Hepatitis E infection. PMID: 23246582
    18. PCOS is associated with increased CD11c expression. PMID: 23118428
    19. Upon expression on surface of human embryonic kidney (HEK)293 cells, alphaXbeta2 supports adhesive, migratory and phagocytic activities of human cells toward Candida albicans. PMID: 22844116
    20. Mice lacking protein tyrosine phosphatase Shp1 specifically in dendritic cells (DCs) develop splenomegaly associated with more CD11c+ DCs. PMID: 22539788
    21. analysis of complement recognition by integrin alphaXbeta2 PMID: 22393018
    22. CD11c+HLADR+ dendritic cells are present in human ovarian follicular fluid, and their maturity correlates with serum estradiol levels in response to gonadotropins. PMID: 22244783
    23. CD11c-positive dendritic cells of transgenic mice express natural killer (NK) cell marker NK1.1 in the thyroid, indicating their NK cell origin. PMID: 21666055
    24. CD11c(HI)-expressing first-trimester decidual macrophages are associated with lipid metabolism and inflammation; CD11c(LO)-expressing macrophages are involved in extracellular matrix formation, muscle regulation and tissue growth. PMID: 21257965
    25. CD56(bright)CD11c(positive) cells play a key role in the interleukin (IL)-18-mediated proliferation of gammadelta T cells. PMID: 21239711
    26. During hypertriglyceridemia, monocytes internalize lipids, upregulate CD11c/CD18, and increase adhesion to VCAM-1. PMID: 21030716
    27. Expression of dendritic cell markers CD11c/BDCA-1 and CD123/BDCA-2 in coronary artery disease upon activation in whole blood. PMID: 20888334
    28. Data revealed that alpha(X)beta(2) in the extended-open headpiece conformation had high affinity for ligand, whereas both the bent conformation and the extended-closed headpiece conformation represented the low affinity state. PMID: 20679211
    29. CD11c-positive dendritic cells play an important role in CD8 T cell responses following replication-defective adenovirus serotype 5 immunization, but striking redundancy for innate cytokines and signaling is revealed. PMID: 20610651
    30. CD11c expression is rare in MCL and may aid in differentiation of CD5+ B-cell neoplasms PMID: 20660331
    31. Depletion of CD11c-positive dendritic cells (DCs) increases the susceptibility of CD11c-diphtheria toxin receptor transgenic mice to infection with cell-free virus in both CD4 cell and non-CD4 fractions. PMID: 20382884
    32. CD141+ dendritic cells are the only cells in human blood that express the chemokine receptor XCR1 and respond to the specific ligand XCL1 by Ca2+ mobilization and potent chemotaxis. PMID: 20479115
    33. Data show high expression of CD86 and CD11C, moderate expression of CD1a and CD123, low levels of CD83 on dendritic cells after induction by GM-CSF and IL-4. PMID: 19257981
    34. There was increased expression of CD11c in monocytes of responders to adalimumab monotherapy. PMID: 20032971
    35. Structure of an integrin with an alphaI domain, complement receptor type 4. PMID: 20033057
    36. Diet-induced obesity increased CD11c in both adipose tissue and blood. PMID: 19910635
    37. Activation of the CD11c gene promoter is mediated by Puralpha during phorbol myristate acetate-induced differentiation of monocytic U937 cells. PMID: 11937543
    38. The presence of CR1 (CD35) and CR4 (CD1c/CD18) on HUVEC indicates that endothelial cells (EC) have the potential to bind C3b and iC3b, respectively, which both mediate biological effects in the course of complement activation. PMID: 12083416
    39. serum amyloid P component does not circulate in complex with C4-binding protein (CD11c antigen), fibronectin or any other major protein ligand PMID: 12100475
    40. myeloid dendritic cells containing this antigen are able to stimulate T lymphocytes PMID: 12351396
    41. abnormal expression of the CD11c gene characteristic of hairy cell leukemia is dependent upon activation of the proto-oncogenes ras and junD PMID: 12576324
    42. adhesion of human neutrophil granulocytes to fibrinogen is greatly increased by plasmin digestion in a mode where alphaXbeta2 dominates the integrin-dependent binding PMID: 15665082
    43. The maturation of dendritic cells induced by CD11c- T cells through TNF-alpha production appears to result in the efficient expansion and activation of killer cells. PMID: 15900581
    44. expression of the CD11c gene is regulated by PLD1 and is enhanced by Se-MSC during PMA-induced U937 differentiation. PMID: 16716806
    45. The results from this study present TANGO as a novel ligand for CD11c, regulating migratory processes of hematopoietic cells. PMID: 17726152
    46. These data indicate that AP-2 and Ets-1 regulated expression of integrin alpha10 plays a role in migration of malignant melanoma cells. PMID: 17726260
    47. Expression of alpha10 increases during aggregate culture of mesenchymal stem cells in a chondrogenic medium. PMID: 18047418
    48. CD11c transgene identifies a discrete network of dendritic cells in mouse embryonic central nervous system and in postnatal brain cells. PMID: 18386786
    49. The CD11c antibody was both sensitive and specific for hairy cell leukemia, even in cases with minimal infiltration. PMID: 18580071
    50. CD11c levels decreased in response to anti-TB treatment. CD11c/Arg47Trp polymorphism is not associated with pulmonary tuberculosis. PMID: 19237023

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Integrin alpha chain family
  • 组织特异性：
    Predominantly expressed in monocytes and granulocytes.
  • 数据库链接：

    HGNC: 6152

    OMIM: 151510

    KEGG: hsa:3687

    STRING: 9606.ENSP00000268296

    UniGene: Hs.248472