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ITPKC Antibody

  • 货号：
    CSB-PA003041
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HT29 cells using InsP 3-kinase C Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q96DU7
  • 基因名：
  • 别名：
    4 antibody; 5-trisphosphate 3-kinase C antibody; Inositol 1 antibody; inositol 1,4,5 trisphosphate 3 kinase C antibody; Inositol trisphosphate 3 kinase C antibody; Inositol-trisphosphate 3-kinase C antibody; InsP 3 kinase C antibody; InsP 3-kinase C antibody; IP3 3-kinase C antibody; IP3 3KC antibody; IP3K C antibody; IP3KC antibody; IP3KC_HUMAN antibody; Itpkc antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human InsP 3-kinase C.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate.
  • 基因功能参考文献：
    1. This study identified several important polymorphisms in the ITPKC and SLC11A1 genes in Koreans. PMID: 29214786
    2. Genetic variants of ITPKC may have a potential association with HSCR (Hirschsprung disease) susceptibility and/or developmental diseases related to enteric nervous system development. PMID: 28664405
    3. this study shows that the KD-associated genetic polymorphism in inositol-triphosphate 3-kinase C (ITPKC) (rs28493229) has important functional consequences, governing ITPKC protein levels and thereby intracellular calcium, which in turn regulates NLRP3 expression and production of IL-1beta and IL-18. PMID: 27694492
    4. ITPKC polymorphisms are associated with Kawasaki disease. PMID: 24903211
    5. SNP rs7251246 in ITPKC is associated with the severity of Kawasaki disease PMID: 24621571
    6. Our results identify a novel polymorphism for renal function and highlight the importance of ITPKC as a key molecule to regulate calcium signaling. PMID: 24800221
    7. a combinatorial association between ITPKC (rs28493229) and CASP3 (rs113420705) was found in coronary artery lesion formation (P = 0.0227, OR: 3.06)in Taiwanese population PMID: 23894522
    8. functional studies demonstrated that PPP3CC positively influences the protein level of ITPKC, likely by inhibiting phosphorylation of ITPKC and consequently preventing ITPKC from ubiquitin-mediated protein degradation PMID: 23747857
    9. Functional single-nucleotide polymorphisms in ITPKC and CASP3 are associated with susceptibility to Kawasaki's disease (KD). PMID: 21987091
    10. the functional polymorphism rs28493229 in ITPKC significantly contributes to the risk of Kawasaki disease. PMID: 23065250
    11. The C allele of the ITPKC gene rs2290692 is linked to a significantly higher risk for KD in the Han Chinese population studied. PMID: 22361738
    12. ITPKC susceptibility in Kawasaki syndrome is related to its synergy with environmental triggers, such as thimerosal, which alter calcium homeostasis and promote oxidative stress. PMID: 22498790
    13. It was found the G/G genotype and G allele of the inositol 1,4,5-trisphosphate 3-kinase rs28493229 polymorphism may contribute to the risk of cervical squamous cell carcinoma in Taiwanese women. PMID: 22610085
    14. The study failed to prove any association between SNP rs28493229 of ITPKC gene and Kawasaki disease/coronary artery lesions in Chinese patients. PMID: 22161096
    15. results indicated that C-allele of ITPKC SNP rs28493229 is associated with the susceptibility and aneurysm formation in KD patients in a Taiwanese population PMID: 21533171
    16. Single nucleotide polymorphism rs28493229 in ITPKC contributes to Kawasaki disease susceptibility through induced hyperimmune function reflected in the BCG reactivation. PMID: 20805785
    17. A statistically significant association was not found between the ITPKC gene single-nucleotide polymorphism rs28493229 and Kawasaki disease or coronary artery lesions in Taiwanese children. PMID: 20045869
    18. results highlight the potential role of the three isoforms of InsP3 3-kinase as direct InsP3 metabolizing enzymes and direct regulators of Ca2+ responses to extracellular signals PMID: 12747803
    19. ITPKC acts as a negative regulator of T-cell activation through the Ca2+/NFAT signaling pathway, and the C allele may contribute to immune hyper-reactivity in Kawasaki disease. PMID: 18084290

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  • 相关疾病：
    Kawasaki disease (KWD)
  • 亚细胞定位：
    Nucleus. Cytoplasm. Note=Shuttles actively between nucleus and cytoplasm with both nuclear import and nuclear export activity.
  • 蛋白家族：
    Inositol phosphokinase (IPK) family
  • 组织特异性：
    Highly expressed in pancreas, skeletal muscle, liver, placenta and weakly in kidney and brain.
  • 数据库链接：

    HGNC: 14897

    OMIM: 606476

    KEGG: hsa:80271

    STRING: 9606.ENSP00000263370

    UniGene: Hs.515415