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ITPR2 Antibody

  • 货号：
    CSB-PA247118
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA247118(ITPR2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q14571
  • 基因名：
  • 别名：
    4 antibody; 5-trisphosphate receptor antibody; Inositol 1 4 5 trisphosphate receptor type 2 antibody; Inositol 1,4,5-trisphosphate receptor type 2 antibody; Inositol 145 trisphosphate receptor type 2 antibody; InsP3 R2 antibody; InsP3R2 antibody; IP3 R2 antibody; IP3 receptor antibody; IP3 receptor isoform 2 antibody; IP3R 2 antibody; IP3R2 antibody; ITPR 2 antibody; Itpr2 antibody; ITPR2_HUMAN antibody; Type 2 inositol 1 4 5 trisphosphate receptor antibody; Type 2 inositol 1 antibody; Type 2 inositol 145 trisphosphate receptor antibody; Type 2 InsP3 receptor antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human ITPR2
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA.
  • 基因功能参考文献：
    1. we systematically evaluating RCC risk-associated SNPs indentified from previous GWAS in a Chinese population, finding that one SNP located in PDZD2 and two SNPs located in ITPR2 were ccRCC-risk associated in Chinese population. PMID: 26918600
    2. Data suggest miR-1290 as the new oncomiR involved in laryngeal squamous cell carcinoma pathogenesis probably through downregulation of its target genes MAF and ITPR2. PMID: 26694163
    3. results show a functional role of calcium release by the ITPR2 channel and its subsequent accumulation in the mitochondria PMID: 24797322
    4. High expression of inositol 1,4,5-trisphosphate receptor, type 2 is associated with acute myeloid leukemia. PMID: 25779662
    5. Disrupting IP3R/Bcl-2 interaction therefore leads in those cells to increased Ca(2) release and apoptosis. Intriguingly, IP3R2 is not only implicated in apoptosis but also in the induction of senescence, another tumour-suppressive mechanism. PMID: 25499268
    6. A genome-wide association study identifies ITPR2 as a susceptibility gene for Kashin-Beck disease in Han Chinese. PMID: 25303641
    7. Loss of InsP3R2-mediated calcium release causes isolated anhidrosis in humans. PMID: 25329695
    8. ITPR2 and hypertrophy specific gene expression is regulated, in part, by a positive feedback regulation between InsP3R2 and calcineurin-NFATc signaling pathways. PMID: 24415751
    9. These data suggest that ER Ca(2+) released by IP(3) receptors may be detrimental in amyotrophic lateral sclerosis and that motor neurons are vulnerable to impaired Ca(2+) metabolism. PMID: 23131553
    10. Functional IP3R2s are expressed in the mouse sinoatrial node and could serve as an additional divalent calcium ion-dependent mechanism in modulating cardiac pacemaker. PMID: 21852551
    11. ITPR2 is a functional target gene of the BACH1 transcription factor according to ChIP-seq and knockdown analysis in HEK 293 cells. PMID: 21555518
    12. The result of this study suggested that ITPR2 that do not modulate the risk for SALS in the German population. PMID: 19464757
    13. The knock down of IP3R-2 significantly reduced the intracellular Ca2+ response and this reduced Ca2+ response did not affect the activation of CREB but significantly decreased the activation of NFAT. PMID: 21063100
    14. Dystrophic (RCDMD) human muscle cells show 5-fold overexpression of IP(3)R2 and down-regulation of IP(3)R3 compared with normal human muscle cells. PMID: 20395455
    15. Antibodies are detected most frequently in rheumatoid arthritis. PMID: 17437169
    16. Genetic variation is susceptibility factor for amyotrophic lateral sclerosis(ALS). Involved in glutamate-mediated neurotransmission, is one of main regulators of intracellular calcium concentrations, and has important role in apoptosis. PMID: 17827064
    17. Provide evidence for a functional role of the de novo coupling between hTRPC1 and IP3RII in the activation of store operated calcium entry in platelets. PMID: 18249094
    18. Parathyroid hormone communicates with IP(3)R via "cAMP junctions" that allow local delivery of a supramaximal concentration of cAMP to IP(3)R, directly increasing their sensitivity to IP(3). PMID: 18936250
    19. Elevated InsP(3)R2 expression was also detected in hearts from human patients with heart failure after ischemic dilated cardiomyopathy, as well as in aortic-banded hypertrophic mouse hearts. PMID: 19549843
    20. Clinical trial and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 18519826

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  • 相关疾病：
    Anhidrosis, isolated, with normal sweat glands (ANHD)
  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    InsP3 receptor family
  • 组织特异性：
    Isoform Short is found in skeletal muscle and heart.
  • 数据库链接：

    HGNC: 6181

    OMIM: 106190

    KEGG: hsa:3709

    STRING: 9606.ENSP00000370744

    UniGene: Hs.512235