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IVNS1ABP Antibody

  • 中文名称：
    IVNS1ABP兔多克隆抗体
  • 货号：
    CSB-PA011923GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y6Y0
  • 基因名：
    IVNS1ABP
  • 别名：
    IVNS1ABP antibody; ARA3 antibody; FLARA3 antibody; KIAA0850 antibody; KLHL39 antibody; NS1 antibody; NS1BP antibody; HSPC068 antibody; Influenza virus NS1A-binding protein antibody; NS1-BP antibody; NS1-binding protein antibody; Aryl hydrocarbon receptor-associated protein 3 antibody; Kelch-like protein 39 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human IVNS1ABP
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization. Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription. In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors. Inhibits pre-mRNA splicing (in vitro).; (Microbial infection) Involved in the alternative splicing of influenza A virus M1 mRNA through interaction with HNRNPK, thereby facilitating the generation of viral M2 protein.
  • 基因功能参考文献：
    1. Data show that heterogeneous nuclear ribonucleoprotein K (hnRNP K) and influenza virus NS1A binding protein (NS1-BP) regulate host splicing events and that viral infection causes mis-splicing of some of these transcripts. PMID: 29921878
    2. Our study identifies KLHL39 as a negative regulator of Cul3-KLHL20 ubiquitin ligase and reveals a role of KLHL39-mediated PML and DAPK stabilization in colon cancer metastasis. PMID: 25619834
    3. NS1-BP-hnRNPK complex is a key mediator of influenza A virus gene expression. PMID: 23825951
    4. This study provided evidence that miRNA-548an is involved in the regulation of NS1ABP. PMID: 24210102
    5. These findings further support the distinct roles of alpha-enolase and its MBP-1 variant in maintaining cell homeostasis. Moreover, these data suggest a novel function for NS1-BP in the control of cell proliferation. PMID: 17996313

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton. Nucleus, nucleoplasm.
  • 数据库链接：

    HGNC: 16951

    OMIM: 609209

    KEGG: hsa:10625

    STRING: 9606.ENSP00000356468

    UniGene: Hs.497183