Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. Igfbp1 Antibody

Igfbp1 Antibody

  • 货号：
    CSB-PA011095LA01MO
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: HepG2 whole cell lysate, Mouse heart tissue, Mouse kidney tissue, Mouse brain tissue, Mouse skeletal muscle tissue
      All lanes: Igfbp1 antibody at 0.6µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 30 kDa
      Observed band size: 50 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Mus musculus (Mouse) Igfbp1 Polyclonal antibody
  • Uniprot No.：
    P47876
  • 基因名：
    Igfbp1
  • 别名：
    Igfbp1 antibody; Igfbp-1 antibody; Insulin-like growth factor-binding protein 1 antibody; IBP-1 antibody; IGF-binding protein 1 antibody; IGFBP-1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Mouse, Human
  • 免疫原：
    Recombinant Mouse Insulin-like growth factor-binding protein 1 protein (26-272AA)
  • 免疫原种属：
    Mus musculus (Mouse)
  • 标记方式：
    Non-conjugated

    本页面中的产品，Igfbp1 Antibody (CSB-PA011095LA01MO)，的标记方式是Non-conjugated。对于Igfbp1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA011095LB01MO Igfbp1 Antibody, HRP conjugated ELISA
    FITC CSB-PA011095LC01MO Igfbp1 Antibody, FITC conjugated
    Biotin CSB-PA011095LD01MO Igfbp1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.
  • 基因功能参考文献：
    1. the hepatokine IGFBP1 is a critical liver-bone hormonal relay that promotes osteoclastogenesis and bone resorption as well as an essential mediator of FGF21-induced bone loss PMID: 26456333
    2. Data suggest expression of Igfbp1 in liver is regulated by dietary factors; carnosine supplementation down-regulates expression of Igfbp1 in liver of obese/diabetic mice; mechanism involves suppression of Hif1a (hypoxia inducible factor 1 alpha). PMID: 25869614
    3. serum IGFBPI protein could provide an easily measured biomarker for early detection of alcohol-induced liver injury in humans PMID: 24152801
    4. These results show that RTEF-1-stimulated IGFBP-1 expression may be central to the mechanism by which RTEF-1 attenuates blood glucose levels. PMID: 22843786
    5. Global deletion of Igfbp1 in a c-Myc transgenic model did not accelerate the development of prostate cancer. Global Igfbp1 deletion did result in a significant increase in body weight and body fat mass. PMID: 21903863
    6. IGFBP-1 functions as a critical hepatic survival factor in the liver by reducing the level of proapoptotic signals PMID: 12511596
    7. IGFBP-1 may support liver regeneration at least in part via its effect on MAPK/ERK and C/EBP beta activities. These findings are the first demonstration of the involvement of IGFBP-1 in the regulation of in vivo mitogenic signaling pathways. PMID: 12556485
    8. Induction of IFGBP1 expression by amino acid deprivation of HepG2 hepatoma cells involves both a transcriptional activation and an mRNA stabilization due to its 3'UTR. PMID: 15862298
    9. high concentrations of circulating IGFBP-1 are sufficient to cause fetal growth restriction in an animal model PMID: 16293667
    10. the IGFBP-1 gene is a primary target of peroxisome proliferator-activated receptors PMID: 17062566
    11. IGFBP-1 may have an important regulatory role in vivo and in the pathogenesis of type 2 diabetes, in which loss of insulin release is an early pathogenetic event PMID: 17693389
    12. Ahr regulates Igfbp-1 and Lpl expression in the liver. TCDD treatment did not increase the Igfbp-1 and Lpl mRNA levels in Ahr knockout mice. PMID: 18827440
    13. the embryopathic effects are associated with knockdown of EGNL1 and the associated induction of Igfbp1 mRNA in the placenta, but not the embryo. PMID: 19683511

    显示更多

    收起更多

  • 亚细胞定位：
    Secreted.
  • 数据库链接：

    KEGG: mmu:16006

    STRING: 10090.ENSMUSP00000020704

    UniGene: Mm.21300