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KATNA1 Antibody

  • 货号：
    CSB-PA011990GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O75449
  • 基因名：
    KATNA1
  • 别名：
    Katanin p60 ATPase containing subunit A1 antibody; Katanin p60 ATPase-containing subunit A1 antibody; Katanin p60 subunit A1 antibody; KATNA1 antibody; KTNA1_HUMAN antibody; OTTHUMP00000017392 antibody; OTTHUMP00000042860 antibody; p60 katanin antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human KATNA1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
  • 基因功能参考文献：
    1. CAMSAP3 precisely coordinates with dynein and katanin to regulate the microtubule detachment process. PMID: 28386021
    2. Katanin Severing and Binding Microtubules Are Inhibited by Tubulin Carboxy Tails PMID: 26682813
    3. analysis of spastin's microtubule-binding properties and comparison with katanin PMID: 23272056
    4. Data propose a model in which spatial rearrangement of the p60 katanin N-terminal domain relative to the C-terminal AAA domain may be important for productive ATP hydrolysis towards MT-severing. PMID: 22325007
    5. Katanin p60 was aberrantly expressed during prostate cancer progression. The elevated katanin p60 expression may contribute to cancer cell metastasis via a stimulatory effect on cell motility. PMID: 21681775
    6. A common substrate recognition mode conserved between katanin p60 and VPS4 governs microtubule severing and membrane skeleton reorganization PMID: 20339000

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  • 亚细胞定位：
    Cytoplasm. Midbody. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, spindle.
  • 蛋白家族：
    AAA ATPase family, Katanin p60 subunit A1 subfamily
  • 数据库链接：

    HGNC: 6216

    OMIM: 606696

    KEGG: hsa:11104

    STRING: 9606.ENSP00000335106

    UniGene: Hs.450175