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KCNK10 Antibody

  • 货号：
    CSB-PA345388
  • 规格：
    ￥880
  • 图片：
    • Western blot analysis of 1) Mouse BrainTissue, 2)Rat Brain Tissue, 3) Jurkat with KCNK10(TREK-2) Rabbit pAb diluted at 1:2,000.
    • Immunohistochemical analysis of paraffin-embedded Rat BrainTissue using KCNK10 (TREK-2) Rabbit pAb diluted at 1:200.
  • 其他：

产品详情

  • Uniprot No.：
    P57789
  • 基因名：
    KCNK10
  • 别名：
    KCNK10; TREK2; Potassium channel subfamily K member 10; Outward rectifying potassium channel protein TREK-2; TREK-2 K(+ channel subunit
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic Peptide
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-2000
    IHC 1:100-200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids.
  • 基因功能参考文献：
    1. The M2-glycine hinge controls the macroscopic currents of TREK1 channels. PMID: 28676394
    2. This study showed that KCNK10 gene involved in neuronal growth and cerebellum development and associated with neurological and psychological disorders. PMID: 26381449
    3. The selectivity filter conformations of alternative translation initiation isoforms and wild type human TREK-2 are similar in the S4 site and pHo position. PMID: 26271386
    4. Results suggest that the cytosolic C-terminal domain and the bottom of transmembrane segment M2 are required for the 2-aminoethoxydiphenyl borate activation on TREK-2 channels PMID: 25982558
    5. How ion channels sense mechanical force: insights from mechanosensitive K2P channels TRAAK, TREK1, and TREK2. PMID: 26332952
    6. Modulation of K2P 2.1 and K2P 10.1 K(+) channel sensitivity to carvedilol by alternative mRNA translation initiation PMID: 25168769
    7. PLD2, but not PLD1, directly binds to the C terminus of TREK1 and TREK2. PMID: 25197053
    8. crystal structures of TREK-2 channel in 2 conformations and in complex with norfluoxetine, a state-dependent blocker of TREK channels; results provide an explanation for TREK channel mechanosensitivity, regulation by diverse stimuli and possible off-target effects of Prozac PMID: 25766236
    9. High TREK-2 expression is associated with epithelial ovarian cancer. PMID: 23479219
    10. Tissue-specific mRNA splicing regulates alternative translation initiation (ATI) of human K(2P)10.1 K+ background channels via recombination of 5 nucleotide motifs. PMID: 21669980
    11. Expression pattern and functional characteristics of two novel splice variants of the two-pore-domain potassium channel TREK-2. PMID: 11897838
    12. Predicts the role of TREK-2 in brain ischemia, memory and other tissues.[REVIEW] PMID: 17689202

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Two pore domain potassium channel (TC 1.A.1.8) family
  • 组织特异性：
    Abundantly expressed in pancreas and kidney and to a lower level in brain, testis, colon, and small intestine. Isoform b is strongly expressed in kidney (primarily in the proximal tubule) and pancreas, whereas isoform c is abundantly expressed in brain.
  • 数据库链接：

    HGNC: 6273

    OMIM: 605873

    KEGG: hsa:54207

    STRING: 9606.ENSP00000310568

    UniGene: Hs.560255