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KCNMB3 Antibody

  • 货号：
    CSB-PA878838LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of U251 cells with CSB-PA878838LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) KCNMB3 Polyclonal antibody
  • Uniprot No.：
    Q9NPA1
  • 基因名：
  • 别名：
    BK channel subunit beta 3 antibody; BK channel subunit beta-3 antibody; BKbeta 3 antibody; BKbeta3 antibody; Calcium activated potassium channel beta 3 subunit antibody; Calcium activated potassium channel subfamily M subunit beta 3 antibody; Calcium activated potassium channel subunit beta 3 antibody; Calcium-activated potassium channel antibody; Calcium-activated potassium channel subunit beta-3 antibody; Charybdotoxin receptor subunit beta 3 antibody; Charybdotoxin receptor subunit beta-3 antibody; EG435726 antibody; Gm5707 antibody; Hbeta 3 antibody; Hbeta3 antibody; K(VCA)beta 3 antibody; K(VCA)beta-3 antibody; KCMB3_HUMAN antibody; KCNMB 2 antibody; KCNMB 3 antibody; KCNMB2 antibody; KCNMB3 antibody; KCNMBL antibody; Large conductance voltage and Ca2+ activated potassium channel Maxi K beta 3 subunit antibody; Maxi K channel subunit beta 3 antibody; Maxi K channel subunit beta-3 antibody; Potassium channel, calcium-activated large conductance, subfamily M, beta member 3 antibody; Potassium large conductance calcium activated channel beta 3 subunit antibody; Potassium large conductance calcium activated channel subfamily M beta member 3 antibody; Slo beta 3 antibody; Slo-beta-3 antibody; subfamily M subunit beta-3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Calcium-activated potassium channel subunit beta-3 protein (82-207AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，KCNMB3 Antibody (CSB-PA878838LA01HU)，的标记方式是Non-conjugated。对于KCNMB3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA878838LB01HU KCNMB3 Antibody, HRP conjugated ELISA
    FITC CSB-PA878838LC01HU KCNMB3 Antibody, FITC conjugated
    Biotin CSB-PA878838LD01HU KCNMB3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Antigen Affinity purified & Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer.
  • 基因功能参考文献：
    1. Single-nucleotide polymorphism in KCNMB3 gene is associated with Insulin Resistance. PMID: 23826284
    2. The frequency of the delA750 mutation was significantly increased in idiopathic generalized epilepsy (7.9%) compared to that in the controls (5.5%; P = 0.016, one-sided; OR = 1.52; 95%-CI: 1.05-2.21). PMID: 16958040
    3. The KCNMB3 isoforms beta3a-d may have unique functions in primates. PMID: 18591419
  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    KCNMB (TC 8.A.14.1) family, KCNMB3 subfamily
  • 组织特异性：
    Isoform 1, isoform 3 and isoform 4 are widely expressed. Isoform 2 is expressed placenta, pancreas, kidney and heart. Isoform 1 and isoform 3 are highly expressed in pancreas and testis.
  • 数据库链接：

    HGNC: 6287

    OMIM: 605222

    KEGG: hsa:27094

    STRING: 9606.ENSP00000319370

    UniGene: Hs.591285