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KCNMB4 Antibody

  • 货号：
    CSB-PA003201
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HepG2 cells using MaxiKβ Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q86W47
  • 基因名：
  • 别名：
    BK channel subunit beta 4 antibody; BK channel subunit beta-4 antibody; BKbeta4 antibody; Calcium activated potassium channel beta 4 subunit antibody; Calcium activated potassium channel subfamily M subunit beta 4 antibody; Calcium activated potassium channel subunit beta 4 antibody; Calcium-activated potassium channel antibody; Calcium-activated potassium channel subunit beta-4 antibody; Charybdotoxin receptor subunit beta 4 antibody; Charybdotoxin receptor subunit beta-4 antibody; Hbeta4 antibody; K(VCA)beta 4 antibody; K(VCA)beta-4 antibody; KCMB4_HUMAN antibody; KCNMB 4 antibody; Kcnmb4 antibody; Large conductance calcium dependent potassium ion channel beta 4 subunit antibody; Maxi K channel subunit beta 4 antibody; Maxi K channel subunit beta-4 antibody; Potassium large conductance calcium activated channel subfamily M beta member 4 antibody; Slo beta 4 antibody; Slo-beta-4 antibody; subfamily M subunit beta-4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human MaxiKβ.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations.
  • 基因功能参考文献：
    1. Two recurrent fusion genes associated with the 12q locus, LRP1-SNRNP25 and KCNMB4-CCND3, were by RT-PCR, Sanger sequencing and FISH, and were found to be osteosarcoma specific in a validation cohort of 240 other sarcomas. PMID: 25300797
    2. Recombinant martentoxin selectively blocks KCNMA1/KCNMB4 channels. PMID: 24759175
    3. BK channel beta4 subunit influences sensitivity and tolerance to alcohol by altering its response to kinases PMID: 25190810
    4. Study shows that beta4 subunit of the MaxiK channel has no potential endocytic signal and 2 specific amino acids in the functional basic motif retention/retrieval trafficking signal at the C-terminus may play a role in controlling cellular excitability PMID: 24486049
    5. our data suggest that the rs398702 variant in the KCNMB4 gene is unlikely to influence significantly the risk of developing mesial temporal lobe epilepsy or its severity PMID: 23623847
    6. These results suggest that fast-gating, type I BK channels lacking beta4 can increase neuronal excitability in response to reduced phosphatase activity and activation of calcium channels. PMID: 21848922
    7. Structural basis for toxin resistance of beta4-associated calcium-activated potassium (BK) channels PMID: 18559348
    8. The beta4 subunit controls ethanol tolerance at the molecular, cellular, and behavioral levels, and could determine individual differences in alcohol abuse and alcoholism, as well as represent a therapeutic target for alcoholism. PMID: 18981408
    9. results argue that, for native mouse Slo3 channels, the beta4 subunit must be considered as a potential interaction partner and, furthermore, that KCNMB subunits may have functions unrelated to regulation of the Slo1 alpha subunit PMID: 19578543

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    KCNMB (TC 8.A.14.1) family, KCNMB4 subfamily
  • 组织特异性：
    Predominantly expressed in brain. In brain, it is expressed in the cerebellum, cerebral cortex, medulla, spinal cord, occipital pole, frontal lobe, temporal lobe, putamen, amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra and thala
  • 数据库链接：

    HGNC: 6289

    OMIM: 605223

    KEGG: hsa:27345

    STRING: 9606.ENSP00000258111

    UniGene: Hs.525529