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KCNRG Antibody

  • 货号：
    CSB-PA847638LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA847638LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) KCNRG Polyclonal antibody
  • Uniprot No.：
    Q8N5I3
  • 基因名：
    KCNRG
  • 别名：
    KCNRG antibody; CLLD4Potassium channel regulatory protein antibody; Potassium channel regulator antibody; Protein CLLD4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Potassium channel regulatory protein (1-229AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，KCNRG Antibody (CSB-PA847638LA01HU)，的标记方式是Non-conjugated。对于KCNRG Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA847638LB01HU KCNRG Antibody, HRP conjugated ELISA
    FITC CSB-PA847638LC01HU KCNRG Antibody, FITC conjugated
    Biotin CSB-PA847638LD01HU KCNRG Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Inhibits potassium fluxes in cells. May regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes.
  • 基因功能参考文献：
    1. The haploinsufficiency of KCNRG might be relevant to the progression of chronic lymphocytic leukemia (CLL)and multiple myeloma(MM) at least in a subset of patients. PMID: 20237900
    2. KCNRG is an ER-associated protein, which is proposed to regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes. PMID: 19968958
    3. the primary characterization of a new gene KCNRG mapped at chromosome band 13q14.3; is a candidate for a B-cell chronic lymphocytic leukemia and prostate cancer tumor suppressor gene PMID: 12650944
    4. Results suggest that genetic alterations and the expression of KCNRG might play an important role in the development and/or progression of a subset of hepatocellular carcinoma. PMID: 16819283
    5. Autoantibodies to KCNRG were present in 7 of the 8 patients with respiratory symptoms in autoimmune polyendocrine syndrome type 1 PMID: 19251657
    6. KCNRG suppresses K+ channel activity in human prostate cell line LNCaP. PMID: 12650944

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  • 亚细胞定位：
    Endoplasmic reticulum.
  • 组织特异性：
    Ubiquitous in normal tissues and expressed in some tumor tissues.
  • 数据库链接：

    HGNC: 18893

    OMIM: 607947

    KEGG: hsa:283518

    STRING: 9606.ENSP00000324191

    UniGene: Hs.660161