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KDM2B Antibody

  • 货号：
    CSB-PA836777LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescent analysis of A549 cells using CSB-PA836777LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) KDM2B Polyclonal antibody
  • Uniprot No.：
    Q8NHM5
  • 基因名：
    KDM2B
  • 别名：
    [Histone-H3]-lysine-36 demethylase 1B antibody; CXXC-type zinc finger protein 2 antibody; CXXC2 antibody; F box and leucine rich repeat protein 10 antibody; F box protein FBL10 antibody; F-box and leucine-rich repeat protein 10 antibody; F-box protein FBL10 antibody; F-box/LRR-repeat protein 10 antibody; Fbl10 antibody; FBXL10 antibody; JEMMA (Jumonji domain EMSY interactor methyltransferase motif) protein antibody; JHDM1B antibody; JmjC domain-containing histone demethylation protein 1B antibody; Jumonji C domain containing histone demethylase 1B antibody; Jumonji domain-containing EMSY-interactor methyltransferase motif protein antibody; kdm2b antibody; KDM2B_HUMAN antibody; Lysine (K) specific demethylase 2B antibody; Lysine-specific demethylase 2B antibody; PCCX2 antibody; Protein containing CXXC domain 2 antibody; Protein JEMMA antibody; Protein-containing CXXC domain 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Lysine-specific demethylase 2B protein (1274-1336AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，KDM2B Antibody (CSB-PA836777LA01HU)，的标记方式是Non-conjugated。对于KDM2B Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA836777LB01HU KDM2B Antibody, HRP conjugated ELISA
    FITC CSB-PA836777LC01HU KDM2B Antibody, FITC conjugated
    Biotin CSB-PA836777LD01HU KDM2B Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable).
  • 基因功能参考文献：
    1. Data indicate a cell regulatory mechanism through which lysine-specific demethylase 2B (KDM2B) promotes triple negative breast cancer (TNBC) cell proliferation by binding to the promoters of cell cycle inhibitors p15INK4B, p16INK4A, and p57KIP2. PMID: 30060056
    2. SS18-SSX1 deregulates developmental programs to drive transformation by hijacking a transcriptional repressive complex to aberrantly activate gene expression PMID: 29502955
    3. KDM2B regulates EZH2 and BMI1 in HCT116 colon tumor cells. Knockdown of this epigenetic factor induced potent up-regulation of the protein levels of the epithelial markers E-cadherin and ZO-1, while the mesenchymal marker N-cadherin was downregulated. PMID: 29772566
    4. These results establish a clear functional link between the epigenetic factor KDM2B and the regulation of cell adhesion and Rho-GTPases signaling that controls actin reorganization and cell migration. PMID: 29408056
    5. The apoptosis phenotype was partly dependent on HRK upregulation, as HRK knockdown significantly abrogated the sensitization. KDM2B-silenced tumors exhibited slower growth in vivo. Taken together, our findings suggest a novel mechanism, where the key apoptosis components are under epigenetic control of KDM2B in glioblastoma multiforme cells. PMID: 28661478
    6. Data indicate that the reduction of JmjC domain-containing histone demethylase 1B (JHDM1B) leads to a more aggressive cellular phenotype in mammary gland cells, by virtue of its negative regulatory activity on ribosome biogenesis. PMID: 28415746
    7. a novel regulatory role of KDM2B in autophagy and cell growth in gastric cancer cells, is reported. PMID: 28506929
    8. we identified KDM2B, a reader for methylated CpGs, as the target of miR-448 that represses glycolysis and promotes oxidative phosphorylation in gastric cancer PMID: 26989077
    9. High KDM2B expression is associated with Neuroblastomas. PMID: 28684529
    10. novel function of KDM2B in the negative regulation of cell proliferation by assembling an E3 ligase to targeting c-Fos protein degradation that is antagonized by mitogenic stimulations PMID: 26725323
    11. A missense mutation in the KDM2B gene is associated with malignant peripheral nerve sheath tumors. PMID: 28124441
    12. we propose histone demethylase KDM2B and histone methyltransferase SETD1B as the two most plausible candidate genes involved in intellectual disability, autism, epilepsy, and craniofacial anomalies PMID: 27106595
    13. NDY1/KDM2B functions as a master regulator of polycomb complexes and controls self-renewal of breast cancer stem cells. PMID: 24853546
    14. KDM2B is an important mediator of hematopoietic cell development and has opposing roles in tumor progression that are dependent on cellular context. PMID: 26808549
    15. Jhdm1b is a positive regulator of glycolysis, glutaminolysis, and pyrimidine synthesis in HeLa cells. PMID: 25877602
    16. The protein lysine demethylases Kdm2a and Kdm2b regulate the turnover of non-phosphorylated beta-catenin specifically within the nucleus via direct interaction with the fourth and fifth armadillo repeats. PMID: 26004508
    17. the KDM2B/let-7b/EZH2 axis is involved in epigenetic regulation in MDS, with direct effects on di- and tri-methylation of H3K27. PMID: 25225797
    18. KDM2B specifically recognizes non-methylated DNA in CpG islands and recruits the polycomb repressive complex 1 (PRC1). This contributes to histone H2A lysine 119 ubiquitylation and gene repression. PMID: 23256043
    19. Low JHDM1B expression is associated with breast cancers. PMID: 25273595
    20. KDM2B, an H3K36 histone demethylase implicated in bypass of cellular senescence and somatic cell reprogramming, is markedly overexpressed in PDAC, with levels increasing with disease grade and stage, and highest expression in metastases. PMID: 23321669
    21. It was found that JHDM1B mRNA is predominantly expressed in acute myeloid leukemia-derived aldehyde dehydrogenasehigh/CD34+ cells, and that aberrant expression of JHDM1B induces leukemia cell proliferation through modulation of cell cycle progression. PMID: 22086844
    22. a regulatory role of Fbxl10 in cell morphology, chemokine expression, and the metabolic control of fibroblasts. PMID: 22825849
    23. A novel functional role for FBXL10 as an anti-apoptotic molecule, and describe a new apoptotic-related pathway that involves NF-jB/FBXL10/c-Fos/ c-FLIP. PMID: 21252908
    24. Results demonstrate that Fbl10 is a key regulator of c-Jun function. PMID: 17704768
    25. identification of human JHDM1B as a nucleolar protein; JHDM1B preferentially binds the transcribed region of ribosomal DNA to repress the transcription of ribosomal RNA genes PMID: 17994099
    26. validated occurrence of an unusual TG 3' splice site in intron 15 PMID: 17672918

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  • 亚细胞定位：
    Nucleus, nucleolus. Nucleus. Chromosome.
  • 蛋白家族：
    JHDM1 histone demethylase family
  • 数据库链接：

    HGNC: 13610

    OMIM: 609078

    KEGG: hsa:84678

    STRING: 9606.ENSP00000366271

    UniGene: Hs.524800