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KDM4C Antibody

  • 货号：
    CSB-PA920470
  • 规格：
    ￥1100
  • 图片：
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: CSB-PA920470(KDM4C Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes
  • 其他：

产品详情

  • Uniprot No.：
    Q9H3R0
  • 基因名：
    KDM4C
  • 别名：
    bA146B14.1 antibody; GASC 1 protein antibody; GASC-1 protein antibody; GASC1 antibody; Gene amplified in squamous cell carcinoma 1 protein antibody; JHDM3C antibody; JmjC domain containing histone demethylation protein 3C antibody; JmjC domain-containing histone demethylation protein 3C antibody; JMJD2C antibody; Jumonji domain containing 2C antibody; Jumonji domain containing protein 2C antibody; Jumonji domain-containing protein 2C antibody; Kdm4c antibody; KDM4C_HUMAN antibody; Lysine (K) specific demethylase 4C antibody; Lysine demethylase 4C antibody; Lysine-specific demethylase 4C antibody; TDRD14C antibody; Tudor domain containing 14C antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human KDM4C
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.
  • 基因功能参考文献：
    1. JMJD2C regulated the activities of lung cancer cells by directly controlling the expression of CUL4A in JMJD2C over-expression cell line. PMID: 28236704
    2. histone H3 lysine 9 methylation reduction, which may be due to the downregulation of methyltransferase SUV39H2 and the upregulation of demethylase KDM4C, was found in CD4(+) T lymphocytes of Latent autoimmune diabetes in adult patients PMID: 28396876
    3. KDM4C recognition of H3K4me3 stimulates demethylation of H3K9me3 in cis on peptide and mononucleosome substrates. PMID: 26747609
    4. Pharmacological inhibition of KDM4C/PRMT1 suppresses transcription and transformation ability of MLL fusions PMID: 26766589
    5. Data suggest that D396N polymorphism of JmjC domain-containing histone demethylase JMJD2C affects the prognosis of breast cancer by altering caspase-3 cleavage and the ability of double strand DNA break repair which may contribute to therapy resistance. PMID: 24952432
    6. GASC1 expression is higher in adenocarcinoma than squamous cell carcinoma. Smoking decreases GASC1 expression in tumor cells, indicating that tobacco smoke may influence the methylation of histone 3 lysine residues in lung cancer. PMID: 24371038
    7. KDM4C promotes transcriptional activation by removing the repressive histone mark, H3K9me3, from its target genes. Variation in its expression leads to differences in the growth of normal and some cancer cells. PMID: 24285722
    8. KDM4C maintains the sphere-forming capacity in CRCs by mediating the beta-catenin-dependent transcription of JAG1 in a feed-forward manner. PMID: 23698634
    9. analysis of the nickel-induced inhibition of truncated constructs of JMJD2A and JMJD2C histone demethylases using X-ray absorption spectroscopy PMID: 23692052
    10. Patients with GASC1 positive tumors have better breast cancer specific survival and respond better to radiotherapy and hormonal treatment PMID: 23148692
    11. JMJD2C decreases trimethylation of histone H3 at lysine 9, and enhances HIF-1 binding to hypoxia response elements, thereby activating transcription of proteins that are required for metabolic reprogramming and for lung metastasis. PMID: 23129632
    12. JMJD2C displays an optimal activity in vitro at alphaKG concentrations similar to those found in cancer cells, with implications for the regulation of histone demethylation activity in cancer versus normal cells. PMID: 23067339
    13. This study presented that KDM4C showed strong associations with alcohol withdrawal symptoms (p < 5 x 10-5). PMID: 22072270
    14. inhibition measurements showed significant selectivity between KDM4C and KDM6A PMID: 21575637
    15. The strongest association in obsessive-compulsive disorder has been found at rs301443 (P=0.000067) residing between SLC1A1 and JMJD2C at 9p24. PMID: 20410850
    16. GASC1 interacts with H3K9me3; three members of this subfamily of proteins demethylate H3K9me3/me2 in vitro through a hydroxylation reaction requiring iron and alpha-ketoglutarate as cofactors PMID: 16732293
    17. JMJD2C is the histone demethylase implicated in the epigenetic reprogramming during the early embryogenesis. PMID: 17611647
    18. Gene rearrangements of JMJD2C is associated with mucosa-associated lymphoid tissue lymphoma. PMID: 18927281
    19. GASC1 is a driving oncogene in the 9p23-24 amplicon in human breast cancer. PMID: 19784073

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    JHDM3 histone demethylase family
  • 组织特异性：
    Overexpressed in several esophageal squamous cell carcinomas (ESCs).
  • 数据库链接：

    HGNC: 17071

    OMIM: 605469

    KEGG: hsa:23081

    STRING: 9606.ENSP00000370710

    UniGene: Hs.709425