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KDM4D Antibody

  • 货号：
    CSB-PA718355LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA718355LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA718355LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) KDM4D Polyclonal antibody
  • Uniprot No.：
    Q6B0I6
  • 基因名：
    KDM4D
  • 别名：
    JHD3D antibody; JHDM3D antibody; JmjC domain-containing histone demethylation protein 3D antibody; Jumonji domain-containing protein 2D antibody; Kdm4d antibody; KDM4D_HUMAN antibody; Lysine-specific demethylase 4D antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Lysine-specific demethylase 4D protein (337-499AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，KDM4D Antibody (CSB-PA718355LA01HU)，的标记方式是Non-conjugated。对于KDM4D Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA718355LB01HU KDM4D Antibody, HRP conjugated ELISA
    FITC CSB-PA718355LC01HU KDM4D Antibody, FITC conjugated
    Biotin CSB-PA718355LD01HU KDM4D Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.
  • 基因功能参考文献：
    1. A high nuclear expression of KDM4D in samples of pancreatic resection margins significantly and independently predicted an earlier recurrence and could thus be used in the assessment of risk of relapse in clinical practice. PMID: 29599352
    2. The results demonstrate a novel mechanism by which Kdm4d regulates DNA replication by reducing the H3K9me3 level to facilitate formation of preinitiation complex. PMID: 27679476
    3. KDM4B and KDM4D expression may associate with an aggressive subtype of classical Hodgkin lymphoma and be linked with radioresistance PMID: 27630312
    4. KDM4D-RNA interaction is required for KDM4D accumulation at DNA breakage sites PMID: 25714495
    5. PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair. PMID: 24550317
    6. The molecular basis for JMJD2 site specificity revealed by X-ray crystallography. PMID: 23219879
    7. Results demonstrate that JMJD2D can stimulate cell proliferation and survival, suggesting that its inhibition may be helpful in the fight against cancer PMID: 22514644
    8. identified two related histone demethylases, JMJD2A and JMJD2D PMID: 17555712

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    JHDM3 histone demethylase family
  • 数据库链接：

    HGNC: 25498

    OMIM: 609766

    KEGG: hsa:55693

    STRING: 9606.ENSP00000334181

    UniGene: Hs.503598