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  4. KIAA0226L Antibody

KIAA0226L Antibody

  • 中文名称：
    KIAA0226L兔多克隆抗体
  • 货号：
    CSB-PA003112GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9H714
  • 基因名：
    RUBCNL
  • 别名：
    C13orf18 antibody; CM018_HUMAN antibody; FLJ21562 antibody; FLJ43762 antibody; KIAA0226 like antibody; KIAA0226L antibody; RP11-247M1.4 antibody; Uncharacterized protein C13orf18 antibody; Uncharacterized protein KIAA0226-like antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Human C13orf18
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Regulator of autophagy that promotes autophagosome maturation by facilitating the biogenesis of phosphatidylinositol 3-phosphate (PtdIns(3)P) in late steps of autophagy. Acts by antagonizing RUBCN, thereby stimulating phosphatidylinositol 3-kinase activity of the PI3K/PI3KC3 complex. Following anchorage to the autophagosomal SNARE STX17, promotes the recruitment of PI3K/PI3KC3 and HOPS complexes to the autophagosome to regulate the fusion specificity of autophagosomes with late endosomes/lysosomes. Binds phosphoinositides phosphatidylinositol 3-phosphate (PtdIns(3)P), 4-phosphate (PtdIns(4)P) and 5-phosphate (PtdIns(5)P). In addition to its role in autophagy, acts as a regulator of lipid and glycogen homeostasis. May act as a tumor suppressor.
  • 基因功能参考文献：
    1. Pacer localizes to autophagic structures and positively regulates autophagosome maturation. PMID: 28306502
    2. Re-activation of C13ORF18 led to partial demethylation of the C13ORF18 promoter and decreased repressive histone methylation. PMID: 23522960
    3. Data suggest that the four-gene methylation panel might provide an alternative triage test after primary high-risk papillomavirus (hr-HPV) testing. PMID: 21796628
    4. Methylation of C13orf18 in cervical scrapings is strongly associated with high-grade cervical intraepithelial neoplasia and cervical cancer. PMID: 19843677
  • 亚细胞定位：
    Cytoplasmic vesicle, autophagosome membrane; Peripheral membrane protein.
  • 组织特异性：
    Expressed weakly in cervical carcinoma cell lines.
  • 数据库链接：

    HGNC: 20420

    KEGG: hsa:80183

    STRING: 9606.ENSP00000374558

    UniGene: Hs.98117