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KIF18A Antibody

  • 货号：
    CSB-PA012315GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q8NI77
  • 基因名：
    KIF18A
  • 别名：
    AU024633 antibody; B130001M12Rik antibody; DKFZp434G2226 antibody; KI18A_HUMAN antibody; KIF 18A antibody; KIF18A antibody; kinesin family member 18A antibody; Kinesin like protein KIF18A antibody; Kinesin-like protein KIF18A antibody; Marrow stromal KIF18A antibody; MGC27627 antibody; MS KIF18A antibody; MS-KIF18A antibody; RGD1561740 antibody; RP23 206C1.1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human KIF18A
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression.
  • 基因功能参考文献：
    1. High KIF18A expression is associated with invasion and metastasis of hepatocellular carcinoma. PMID: 29466986
    2. Low post translational modifications of KIF18A protein is associated with neoplasms. PMID: 28209915
    3. KIF18a role in microtubule assembly PMID: 26912793
    4. Cdk1-mediated inhibitory phosphorylation of Kif18A promotes chromosome oscillations in early metaphase. PP1 induces metaphase plate thinning by directly dephosphorylating Kif18A. PMID: 25048371
    5. Confocal microscopy shows that cells expressing SUMO-resistant Kif18A display a compromised dissociation of BubR1 from kinetochores after anaphase onset. PMID: 25884224
    6. data support a model in which microtubule-attenuating kinesins are molecularly "tuned" to control the dynamics of specific subsets of spindle microtubules PMID: 25208566
    7. a biomarker for hepatocellular carcinoma diagnosis and an independent predictor of overall survival PMID: 25431949
    8. that the human mitotic kinesin-8, KIF18A, directly interacts with PP1gamma through a conserved RVxF motif PMID: 25281536
    9. the motion of yeast (Kip3) and human (Kif18A) kinesin-8s PMID: 23746518
    10. Mechanisms controlling the temporal degradation of Nek2A and Kif18A by the APC/C-Cdc20 complex. PMID: 23288039
    11. Kif18A (kinesin-8) attenuates centromere movement by directly promoting microtubule pausing in a concentration- dependent manner. PMID: 22595673
    12. there is a mutual regulation of kinetochore MT plus-end dynamics and Kif18A accumulation, which may contribute to the highly regulated and ordered changes in kinetochore spindle microtubule dynamics during chromosome congression and oscillation PMID: 22104080
    13. Kif18A controls spindle length independently of its role in chromosome positioning. This is mediated by an ATP-independent spindle microtubule (MT) binding site at C-terminal end of the Kif18A tail that has a strong affinity for MTs in vitro and in cells. PMID: 21885282
    14. The heightened processivity of Kif18A, conferred by its tail domain, thus promotes concentration of Kif18A at K-MT plus ends, where it suppresses their dynamics to control chromosome movements. PMID: 21884977
    15. Kif18A overexpression is associated with colorectal cancer progression. PMID: 21213216
    16. Kinesin (KIF18A) can be potentially used as a blood biomarker to identify asbestosis patients at risk of developing lung cancer. PMID: 21231887
    17. High Kif18A is associated with breast carcinogenesis. PMID: 20595236
    18. The kinesin-8 Kif18A dampens microtubule plus-end dynamics. PMID: 20153196
    19. Kif18A is a dual-functional kinesin and a key component of chromosome congression. PMID: 17346968
    20. Kif18A regulates kinetochore microtubule dynamics to control mitotic chromosome positioning. PMID: 18267093
    21. The current study sheds light on MS-KIF18A a microtubule-dependent kinesin and adds insights on the post-translational modifications that potentially control the protein cellular distribution and its co-association with cytoskeletal proteins. PMID: 18680169
    22. Studies strongly suggest that chromosome congression defects as the result of KIF18A depletion is at least in part mediated through destabilizing kinetochore CENP-E. PMID: 19625775

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  • 亚细胞定位：
    Cell projection, ruffle. Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族：
    TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family
  • 数据库链接：

    HGNC: 29441

    OMIM: 611271

    KEGG: hsa:81930

    STRING: 9606.ENSP00000263181

    UniGene: Hs.301052