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KIRREL3 Antibody

  • 货号：
    CSB-PA811640LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of HepG2 cells with CSB-PA811640LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) KIRREL3 Polyclonal antibody
  • Uniprot No.：
    Q8IZU9
  • 基因名：
    KIRREL3
  • 别名：
    KIRREL3 antibody; KIAA1867 antibody; NEPH2 antibody; UNQ5923/PRO4502/PRO19814Kin of IRRE-like protein 3 antibody; Kin of irregular chiasm-like protein 3 antibody; Nephrin-like protein 2) [Cleaved into: Processed kin of IRRE-like protein 3] antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Kin of IRRE-like protein 3 protein (200-343AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，KIRREL3 Antibody (CSB-PA811640LA01HU)，的标记方式是Non-conjugated。对于KIRREL3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA811640LB01HU KIRREL3 Antibody, HRP conjugated ELISA
    FITC CSB-PA811640LC01HU KIRREL3 Antibody, FITC conjugated
    Biotin CSB-PA811640LD01HU KIRREL3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Synaptic adhesion molecule required for the formation of target-specific synapses. Required for formation of target-specific synapses at hippocampal mossy fiber synapses. Required for formation of mossy fiber filopodia, the synaptic structures connecting dentate granule and GABA neurons. Probably acts as a homophilic adhesion molecule that promotes trans-cellular interactions and stabilize mossy fiber filipodia contact and subsequent synapse formation. Required for the coalescence of vomeronasal sensory neuron axons. May be involved in the hematopoietic supportive capacity of stroma cells; the secreted extracellular domain is directly responsible for supporting hematopoietic stem cells.
  • 基因功能参考文献：
    1. KIRREL3 interacting proteins MAP1B and MYO16 are potential candidates for intellectual disability and autism spectrum disorder. PMID: 25902260
    2. Results presented demonstrate for the first time that there are at least 3 splice variants of Kirrel3 expressed in adult human skeletal muscle, two of which have never previously been identified in human muscle. PMID: 25488023
    3. Alterations in KIRREL3 in patients with mild to severe intellectual disability are reported. PMID: 19012874
  • 相关疾病：
    Mental retardation, autosomal dominant 4 (MRD4)
  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.; [Processed kin of IRRE-like protein 3]: Secreted.
  • 蛋白家族：
    Immunoglobulin superfamily
  • 组织特异性：
    Expressed in fetal and adult brain. Also expressed in kidney, specifically in podocytes of kidney glomeruli. Also expressed in skeletal muscle.
  • 数据库链接：

    HGNC: 23204

    OMIM: 607761

    KEGG: hsa:84623

    STRING: 9606.ENSP00000435466

    UniGene: Hs.376015