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KLF11 Antibody

  • 货号：
    CSB-PA594801
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from 293 cells, Jurkat cells and HuvEc cells, using KLF11 antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) KLF11 Polyclonal antibody
  • Uniprot No.：
    O14901
  • 基因名：
    KLF11
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from Internal of Human KLF11.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcription factor. Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth. Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis.
  • 基因功能参考文献：
    1. Profibrotic gene expression was activated in a primary human peritoneal cell line in response to KLF11 short hairpin RNA and medroxyprogesterone acetate but not estradiol. PMID: 28938437
    2. In endometrial-stromal fibroblasts, KLF11 recruited SIN3A/HDAC (histone deacetylase), resulting in COL1A1-promoter deacetylation and repression PMID: 26935598
    3. Results suggest a role for KLF11 in upregulating MAO-A in depressive disorder and chronic social stress, suggesting that inhibition of the pathways regulated by this transcription factor may aid in the therapeutics of neuropsychiatric illnesses PMID: 25502632
    4. The data suggest a relationship between promoter DNA methylation and KLF11 gene expression in ovarian cancer tumorigenesis. PMID: 25931269
    5. identified an evolutionarily conserved metabolic regulator, Kruppel-like factor 11 (KLF11), as a novel browning transcription factor in human adipocytes that is required for rosiglitazone-induced browning. PMID: 25504365
    6. KLF11 repressed most endometrial CYP enzymes PMID: 25076120
    7. Levels of KLF11 are significantly increased in the postmortem prefrontal cortex of subjects with alcohol dependence compared to controls. PMID: 23915421
    8. KLF11 regulates distinct gene networks. PMID: 24885560
    9. KLF111 represses glycodelin-A levels and influences its role in the ovarian endometrium. PMID: 24060634
    10. KLF11 is a critical transcription factor in the function of mesenchymal cells and, specifically, as a negative regulator of collagen secretion. PMID: 24069400
    11. Data identify a novel pathogenic role for KLF11 in preventing de novo disease-associated fibrosis in endometriosis. PMID: 23555910
    12. The A347S mutation disrupted KLF11-mediated increases in basal insulin levels and promoter activity and blunted glucose-stimulated insulin secretion. PMID: 23589285
    13. Data indicate that median methylation levels of BCAN, HOXD1, KCTD8, KLF11, NXPH1, POU4F1, SIM1, and TCF7L1 were >/=30% higher than in normal samples, representing potential biomarkers for tumor diagnosis. PMID: 22930747
    14. KLF11 has a role in fine-tuning insulin transcription in certain cellular situations rather than representing a major transcriptional activator or repressor of the insulin gene. PMID: 22801105
    15. Kruppel-like factor-11, a transcription factor involved in diabetes mellitus, suppresses endothelial cell activation via the nuclear factor-kappaB signaling pathway. PMID: 23042817
    16. KLF11 is an MAO A regulator and is produced in response to neuronal stress, which transcriptionally activates MAO A. PMID: 22628545
    17. Here we report the characterization of two antagonistic, chromatin-mediated mechanisms by which KLF11 regulated the transcription of the dopamine D2 receptor. PMID: 22375010
    18. A PXVXL HP1-interacting domain identified at position 487-491 of KLF11 mediates the binding of HP1alpha and KLF11 in vitro and in cultured cells. PMID: 22318730
    19. an important role for KLF11 in the regulation of INS transcription via the novel c.-331 KLF site. PMID: 21592955
    20. epigenetic inactivation and subsequent transcriptional repression of the KLF11 gene is quite frequent in MDS. PMID: 20002157
    21. Kruppel-like factor 11 has a role in the regulation of prostaglandin E2 biosynthesis PMID: 20154088
    22. KLF11 is an integrator of progesterone receptor signaling and proliferation in uterine leiomyoma cells. PMID: 20124487
    23. TIEG2 is an activator of Monoamine oxidase B gene expression. PMID: 15024015
    24. novel mechanism in TGF-beta-regulated gene expression: KLF11 potentiates Smad-signaling activity in normal epithelial cells through termination of the negative feedback loop imposed by Smad7. PMID: 15300592
    25. in the presence of cholesterol, KLF11 acts as a dominant repressor of the caveolin-1 gene PMID: 15531587
    26. KLF11 plays a role in the regulation of pancreatic beta cell physiology, and its variants may contribute to the development of diabetes. PMID: 15774581
    27. These results suggest a central role for KLF11 in TGFbeta-induced c-myc repression and antiproliferation. PMID: 17114344
    28. KLF11 A347S and T220M mutations do not contribute to increased risk of diabetes in European-derived populations. PMID: 17130512
    29. results may help to increase the understanding of Tieg3-mediated transcriptional control and to characterize this TGF-beta-induced Sp1/Klf-like transcription factor PMID: 17252542
    30. TIEG2 decreases the levels of the anti-apoptotic protein Bcl-X(L) and inhibits transcription driven by the Bcl-X(L) promoter. PMID: 17308981
    31. Kruppel-like factor 11 inhibits human proinsulin promoter activity in pancreatic beta cells PMID: 17479246
    32. KLF11 may interfere with glucose homeostasis in a Danish general population and that STAT3-mediated up-regulation of KLF11 transcription was impaired by the -1659G>C variant. PMID: 18505768
    33. KLF11 is unlikely to play a major role in the etiology of T2 diabetes among this Native American population. PMID: 18593768
    34. 19 polymorphisms, 6 of which are novel, were identified, but none of them showed association with type 2 diabetes. Functional analyses of these variants showed reduced effects on transcriptional activities of insulin, catalase1, & the Smad7 gene. PMID: 19122346
    35. MODY7 gene, KLF11, is a novel p300-dependent regulator of Pdx-1 (MODY4) transcription in pancreatic islet beta cells. PMID: 19843526

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  • 相关疾病：
    Maturity-onset diabetes of the young 7 (MODY7)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Sp1 C2H2-type zinc-finger protein family
  • 组织特异性：
    Ubiquitous. Higher expression in erythroid cells.
  • 数据库链接：

    HGNC: 11811

    OMIM: 603301

    KEGG: hsa:8462

    STRING: 9606.ENSP00000307023

    UniGene: Hs.12229