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KLF12 Antibody

  • 货号：
    CSB-PA012386GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y4X4
  • 基因名：
    KLF12
  • 别名：
    2700063E05Rik antibody; AI225908 antibody; AI315654 antibody; AP-2 repressor antibody; AP-2rep antibody; AP-2rep transcription factor antibody; AP2REP antibody; B130052C06Rik antibody; D530033K05Rik antibody; HSPC122 antibody; KLF12 antibody; KLF12 zinc finger transcriptional repressor antibody; KLF12_HUMAN antibody; Krueppel like factor 12 antibody; Krueppel-like factor 12 antibody; OTTHUMP00000018503 antibody; Transcriptional repressor AP 2rep antibody; Transcriptional repressor AP-2rep antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human KLF12
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter.
  • 基因功能参考文献：
    1. Results confirmed that KLF12 was highly expressed in nasopharyngeal carcinoma (NPC) tissues, and over-expressed KLF12 promoted NPC cell proliferation, while silencing KLF12 suppressed it. Furthermore, KLF12 was found to be a direct target for miR-1207 at its 3'-UTR mRNA. PMID: 30243935
    2. Data indicate Kruppel-like factor 12 protein (KLF12) as a metastasis-suppressor gene whose loss of function is associated with anoikis resistance through control of the cell cycle. PMID: 26455320
    3. KLF12 promotes tumor growth by directly activating early growth response protein 1 (EGR1). The levels of KLF12 and EGR1 correlate synergistically with a poor prognosis. These results indicate that KLF12 likely plays an important role in CRC and could serve as a potential prognostic marker and therapeutic target. PMID: 27442508
    4. the overexpression of miR-141 augments anoikis resistance in ovarian cancer cells by targeting and repressing the expression of KLF12, which, in turn, competes for binding sites in the survivin promoter with Sp1. The subsequent increase in survivin then protects ovarian cancer cells against anoikis by blocking the intrinsic apoptotic activity. PMID: 28095864
    5. Data show Kruppel-like factor 12 (KLF12) impairs endometrial decidualization by transcriptionally repressing Nur77 protein, and Nur77 overexpression reverses the poor decidual response of endometrial stromal cells (hESCs) in recurrent implantation failure (RIF) patients. PMID: 28359310
    6. SLC29A1 rs760370 and KLF12 rs9543524 SNPs are associated with treatment induced thrombocytopenia in chronic hepatitis C patients treated with PEGIFN2b/ribavirin/combination. PMID: 26750805
    7. our results supported that miR-205 was a miR specific to basal-like breast carcinoma (BLBC). which functioned as tumor suppressor gene through directly targeting and negatively regulating proto-oncogene KLF12. miR-205 dysregulation was involved in invasion and apoptosis. miR-205 and KLF12 provided a potential diagnosis biomarker and therapeutic approach for BLBC. PMID: 27278159
    8. Overexpression of KLF12 is associated with gastric cancer. PMID: 27468717
    9. Elevated KLF12 expression was accompanied by decreased FOXO1 expression in the endometria of patients with repeated implantation failure. PMID: 26223982
    10. overexpression of KLF12 in endometrial stromal cells significantly repressed the expression and secretion of decidualization biomarker genes and their products decidual prolactin and insulin-like growth factor binding protein-1 PMID: 23458459
    11. The KLF12 rs1324913 A allele homozygous genotype is a possible predictor of Rheumatoid Arthritis. PMID: 22150086
    12. no association of genetic polymorphism with rheumatoid arthritis in Spanish and Dutch cohorts PMID: 21658422
    13. In a large UK cohort of patients with rheumatoid arthritis, results have failed to add to the evidence for association at the KLF12 locus reported to be associated with rheumatoid arthritis in independent Spanish cohorts. PMID: 19907058
    14. KLF12 as a new susceptibility gene for rheumatoid arthritis. PMID: 18668548
    15. Overexpression of Kruppel-like factor 12 is associated with gastric cancer progression. PMID: 19588488

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Sp1 C2H2-type zinc-finger protein family
  • 数据库链接：

    HGNC: 6346

    OMIM: 607531

    KEGG: hsa:11278

    STRING: 9606.ENSP00000366894

    UniGene: Hs.373857