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KLF13 Antibody

  • 货号：
    CSB-PA005502
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of L929 cells using KLF13 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y2Y9
  • 基因名：
    KLF13
  • 别名：
    Basic transcription element binding protein 3 antibody; Basic transcription element-binding protein 3 antibody; BTE binding protein 3 antibody; BTE-binding protein 3 antibody; BTEB3 antibody; C2 H2 zinc finger protein antibody; FKLF 2 antibody; FKLF2 antibody; Klf13 antibody; KLF13_HUMAN antibody; Krueppel-like factor 13 antibody; Kruppel like factor 13 antibody; Novel Sp1 like zinc finger transcription factor antibody; Novel Sp1-like zinc finger transcription factor 1 antibody; NSLP1 antibody; RANTES factor of late activated T lymphocytes 1 antibody; RANTES factor of late activated T-lymphocytes 1 antibody; RFLAT 1 antibody; RFLAT-1 antibody; RFLAT1 antibody; Transcription factor BTEB3 antibody; Transcription factor NSLP1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from Human KLF13 around the non-acetylation site of K166.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Represses transcription by binding to the BTE site, a GC-rich DNA element, in competition with the activator SP1. It also represses transcription by interacting with the corepressor Sin3A and HDAC1. Activates RANTES expression in T-cells.
  • 基因功能参考文献：
    1. Results show that cg07814318 methylation in blood was significantly associated with obesity and correlated with several obesity-related physical and biochemical traits. The exome sequencing of KLF13 gene in blood identified nine SNPs within its gene body, and two SNPs as cis-meQTL of cg07814318. The sequencing variations within KLF13 genes could drive dynamic modifications of obesity-related CpG methylation. PMID: 28508896
    2. KLF13 functions as a tumor suppressor protein in PCa, and the pharmacological activation of KLF13 might represent a potential approach for the treatment of prostate cancer. PMID: 29843216
    3. Our results suggest the cg07814318 site could be involved in orexigenic processes, and also implicate KLF13 in obesity. Our findings are the first to associate methylation levels in blood with brain activity in obesity-related regions, and further support previous findings between ghrelin, brain activity and genetic differences. PMID: 28194012
    4. KLF13 is critical for the activation of the HPV productive life cycle and is likely involved in initiation and progression of cervical cancer. PMID: 27041562
    5. Knockdown of either FBW7gamma or GSK3beta by small interfering RNA increases KLF13 expression in resting human T lymphocytes. PMID: 22797700
    6. No associations were found between maternal genetic polymorphisms in RANTES (-403G/A) and mother-to-child HIV-1 transmission; plasma, cervical and breastmilk viral loads; or breastmilk chemokine concentrations. PMID: 20518834
    7. KLF13 contributes to malignancy in oral cancer cells and may be a useful biomarker fo early detection and da possible target for therapy. PMID: 20539070
    8. Data support cross-regulation among BMP2, KLF9, and KLF13 to maintain progesterone sensitivity in stromal cells undergoing differentiation and suggest that loss of this network compromises establishment of uterine receptivity and implantation success. PMID: 20410205
    9. protein analysis of BTEB3 and BTEB4 and their binding to CYP1A1 PMID: 12036432
    10. functional domains and DNA-binding sequences PMID: 12050170
    11. A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes. PMID: 12093895
    12. Feedback mechanism for the transcriptional control of the KLF13 gene in the erythroid environment. PMID: 15716005
    13. KLF13 is a key regulator of late RANTES expression in T lymphocytes PMID: 17074812
    14. Coexpression of PRP4 and KLF13 increases nuclear localization of KLF13 and CCL5 transcription. PMID: 17513757
    15. Transient transfection of Kruppel-like factor 4 suppressed LDLR, steroidogenic acute regulatory protein, and CYP11A PMID: 18056793

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Sp1 C2H2-type zinc-finger protein family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 13672

    OMIM: 605328

    KEGG: hsa:51621

    STRING: 9606.ENSP00000302456

    UniGene: Hs.376443