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KLF17 Antibody

  • 货号：
    CSB-PA795042
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA795042(KLF17 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA795042(KLF17 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q5JT82
  • 基因名：
    KLF17
  • 别名：
    FLJ40160 antibody; KLF17 antibody; KLF17_HUMAN antibody; Krueppel like factor 17 antibody; Krueppel-like factor 17 antibody; Novel zinc finger protein antibody; RP4 675G8.1 antibody; RP4675G8.1 antibody; Zfp393 antibody; Zinc finger protein 393 antibody; ZNF393 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Fusion protein of Human KLF17
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development.
  • 基因功能参考文献：
    1. Low Expressions of KLF17 is associated with lung adenocarcinoma. PMID: 28454121
    2. Suggest that KLF17 inhibits esophageal carcinoma development and may serve as a potential therapeutic target. PMID: 26617836
    3. Enhanced KLF17 expression sensitizes ERalpha-positive breast cancer cells to endocrine therapy.KLF17-ERalpha interaction plays a potential role in inhibition of ERalpha-dependent breast cancer progression. PMID: 27107895
    4. KLF17 empowers TGF-beta/Smad signaling by targeting Smad3-dependent pathway to suppress tumor growth and metastasis during cancer progression. PMID: 25766320
    5. Tumor-suppressive p53 signaling is critical for KLF17 to inhibit cancer metastasis in Non-small Cell Lung Cancer. PMID: 25911104
    6. A small subset of Myoepithelial tumors harbor FUS rearrangements, two thirds of them being associated with KLF17 fusion. PMID: 25706482
    7. In this review, we focus on the functions, roles, and regulatory networks of these five KLFs in HCC, summarize key pathways, and propose areas for further investigation PMID: 25652467
    8. The reduced expression of KLF17 promoted the motility and proliferation ability of TPC1 cells by altering the expression of tight junction protein 1 and Snai1, and activating the AKT pathway by upregulating inhibitor of DNA binding 1. PMID: 25109837
    9. mutant p53 enhances cancer progression by inhibiting KLF17 expression in invasive breast carcinoma cells PMID: 25111898
    10. The reduced expression of KLF17 protein in gastric cancer was correlated with tumor size, pN stage and lymphovascular invasion and was an independent predictor for poor survival in patients undergoing surgery for gastric cancer. PMID: 24947617
    11. KLF17 might be one of the downstream signalling molecules of DJ-1. PMID: 24504364
    12. KLF17 may have an oncogenic role during EEC progression via initiating EMT through the regulation of TWIST1 PMID: 24220291
    13. Overall, these findings suggest a repressing role of KLF17 in tumor invasion PMID: 23325444
    14. it is possible that KLF17 inhibits tumor growth in lung adenocarcinoma. PMID: 22240024
    15. KLF17 has a role in transcriptional regulation of metastasis by Id1 [review] PMID: 19951400
    16. KLF17 is a new member of the Sp/KLF family of transcription factors. PMID: 16460907
    17. demonstrate that KLF17 expression is significantly downregulated in primary human breast cancer samples and that the combined expression pattern of KLF17 and Id1 can serve as a potential biomarker for lymph node metastasis in breast cancer PMID: 19801974

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Sp1 C2H2-type zinc-finger protein family
  • 数据库链接：

    HGNC: 18830

    OMIM: 609602

    KEGG: hsa:128209

    STRING: 9606.ENSP00000361373

    UniGene: Hs.567674