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KPNA6 Antibody

  • 货号：
    CSB-PA012488GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O60684
  • 基因名：
    KPNA6
  • 别名：
    FLJ11249 antibody; IMA7_HUMAN antibody; Importin alpha 7 subunit antibody; Importin alpha S2 antibody; Importin subunit alpha 7 antibody; Importin subunit alpha-7 antibody; IPOA 7 antibody; IPOA7 antibody; Karyopherin alpha 6 antibody; Karyopherin alpha 6 (importin alpha 7) antibody; Karyopherin subunit alpha 6 antibody; Karyopherin subunit alpha-6 antibody; KPNA 6 antibody; KPNA 7 antibody; Kpna6 antibody; KPNA7 antibody; MGC17918 antibody; OTTHUMP00000004532 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Human KPNA6
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
  • 基因功能参考文献：
    1. Development of a pipeline for automated, high-throughput analysis of PSPC1 paraspeckle protein isoforms reveals specific roles for KPNA2, KPNA4 and KPNA6 proteins. PMID: 28240251
    2. the data showed that viral infection induced an elevation of the KPNA6 protein level due to an extension of the KPNA6 half-life via viral interference of the ubiquitin-proteasomal degradation of KPNA6. Notably, KPNA6 silencing or knockout dramatically reduced the replication of PRRSV and ZIKV. PMID: 29444946
    3. a decreased H7N9 influenza A virus polymerase activity when importin-alpha7 was silenced by siRNA, is reported. PMID: 28189564
    4. Bel1 fragment with residues 215-223, which bears the NLS, interacts with KPNA1, KPNA6, and KPNA7. PMID: 25272585
    5. Importin alpha1 and alpha7 are positive regulators of human-like polymerase activity and pathogenicity beyond their role in nuclear transport. PMID: 22275867
    6. Overexpression of KPNA6 facilitates KEAP1 nuclear import and attenuates NRF2 signaling, whereas knockdown of KPNA6 slows down KEAP1 nuclear import and enhances the NRF2-mediated adaptive response induced by oxidative stress. PMID: 21383067
    7. Importin alpha5 and alpha7 bind to Stat3 upon cytokine stimulation. PMID: 16298512

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  • 蛋白家族：
    Importin alpha family
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 6399

    OMIM: 610563

    KEGG: hsa:23633

    STRING: 9606.ENSP00000362728

    UniGene: Hs.470588