Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. KPTN Antibody

KPTN Antibody

  • 货号：
    CSB-PA012492GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y664
  • 基因名：
    KPTN
  • 别名：
    2E4 antibody; actin associated protein 2E4 antibody; actin binding protein antibody; Actin-associated protein 2E4 antibody; Kaptin antibody; Kptn antibody; KPTN protein antibody; KPTN_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human KPTN
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.
  • 基因功能参考文献：
    1. identification of a protein complex (KICSTOR) that is composed of four proteins, KPTN, ITFG2, C12orf66 and SZT2, and that is required for amino acid or glucose deprivation to inhibit mTORC1 in cultured human cells PMID: 28199306
    2. We have demonstrated that mutations in KPTN, encoding kaptin, cause a syndrome typified by macrocephaly, neurodevelopmental delay, and seizures. PMID: 24239382
  • 相关疾病：
    Mental retardation, autosomal recessive 41 (MRT41)
  • 亚细胞定位：
    Lysosome membrane. Cell projection, lamellipodium. Cell projection, stereocilium.
  • 数据库链接：

    HGNC: 6404

    OMIM: 615620

    KEGG: hsa:11133

    STRING: 9606.ENSP00000337850

    UniGene: Hs.25441