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LAMC1 Antibody

  • 货号：
    CSB-PA009776
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of customer's (cat sample) using Laminin γ-1 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    P11047
  • 基因名：
  • 别名：
    LAMB2 antibody; lamc1 antibody; LAMC1_HUMAN antibody; Laminin B2 chain antibody; Laminin subunit gamma-1 antibody; Laminin, gamma 1 (formerly LAMB2) antibody; Laminin-1 subunit gamma antibody; Laminin-10 subunit gamma antibody; Laminin-11 subunit gamma antibody; Laminin-2 subunit gamma antibody; Laminin-3 subunit gamma antibody; Laminin-4 subunit gamma antibody; Laminin-6 subunit gamma antibody; Laminin-7 subunit gamma antibody; Laminin-8 subunit gamma antibody; Laminin-9 subunit gamma antibody; MGC87297 antibody; S-LAM gamma antibody; S-laminin subunit gamma antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat,Monkey
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human Laminin γ-1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
  • 基因功能参考文献：
    1. Polymorphism in the ERalpha gene is associated with an increased risk for advanced Pelvic Organ Prolapse. However, polymorphism in the LAMC1 gene does not seem to be associated with such risk. PMID: 29241914
    2. We conclude that LAMC1 mRNA acts as a trans regulator to stimulate CD151 expression by competing for miR-124 binding in hepatocellular carcinoma cells. PMID: 28524360
    3. Further gene expression analyses demonstrated significantly higher expression of LAMC1 gene in colorectal cancer (CRC) tumor tissues than that in adjacent non-cancerous tissues (P = 0.0004). These findings strongly suggest that the functional SNP located at TFBSs, rs6695837 might contribute to CRC susceptibility, and the exact biological mechanism awaits further research. PMID: 28039327
    4. The rs780094 [1.34 (1.21-1.49); p = 8.57 x 10(-8) ] on chr 2 at the glucokinase regulatory protein (GCKR) locus was similarly significantly associated, while the rs10911205 [1.29 (1.16-1.44); p = 3.52 x 10(-6) ] on chr1 at the laminin subunit gamma-1 (LAMC1) locus showed suggestive association with disease. PMID: 27599772
    5. Our results show that miR-181a is down-regulated in glioblastoma multiforme (GBM) patients. The three target genes, ANGPT2, ARHGAP18 and LAMC1, are negatively correlated with the expression of miR-181a. Moreover, high expression of ANGPT2 or LAMC1 together with large size of GBM is correlated with a shorter median overall survival PMID: 27176932
    6. miR-506 acts as a tumor suppressor and inhibits malignancy of colorectal cancer cells through directly targeting LAMC1. PMID: 27993882
    7. Case Report: Anti-laminin-gamma 1 pemphigoid in patient with generalized pustular psoriasis and psoriasis vulgaris. PMID: 26074471
    8. The identification of laminin gamma 1 (LAMC1) and myeloid cell leukemia 1 (MCL1) as direct targets of miR-22 and miR-29a, respectively, suggested a tumor-suppressive role of these miRNAs. PMID: 26052614
    9. LAMC1 may contribute to the development and progression of uterine carcinoma, likely through enhancing tumor cell motility and invasion. PMID: 26343160
    10. Case Report: occurrence of anti-laminin-gamma1 pemphigoid in a case of autosomal recessive congenital ichthyosis. PMID: 24733442
    11. Data showed that LAMC1 expression is directly regulated by miR-29s. PMID: 24820027
    12. These findings document a pathogenic potential of antibodies targeting the laminin gamma1 N-terminus. PMID: 24300951
    13. carbohydrate moiety (alpha-Gal) on laminin gamma-1 and collagen alpha-1 (VI) chain are possibly common IgE-reactive proteins in the Japanese patients with beef allergy PMID: 24180678
    14. results demonstrate that mutation in either NID1 or LAMC1 disrupts the interaction NID1-LAMC1 complex; findings implicate the extracellular matrix in the pathogenesis of Dandy-Walker spectrum disorders PMID: 23674478
    15. LAMC1 polymorphism could be a protective factor for SLE. PMID: 23039241
    16. Results suggest that laminin gamma1 expression is associated with meningioma grades and could play a role in enhancing tumor invasion. PMID: 23053286
    17. Genetic polymorphism of LAMC1 gene is associated in the pathogenesis of colorectal cancers. PMID: 23266556
    18. Letter: a small but distinct subgroup of both systemic and cutaneous lupus erythematosus patients has antibodies against the C-terminus of laminin gamma1. PMID: 22968451
    19. Autoantibodies in anti-p200 pemphigoid sera are pathogenic while pathogenicity is not mediated by autoantibodies against laminin gamma1. PMID: 22911854
    20. Overexpression of laminin gamma1 immunoreactivity and alteration of its staining pattern may serve as a useful biomarker in serous tubal intraepithelial carcinoma. PMID: 22892598
    21. Mutations in the coding sequence of LAMC1 and DLGH1 may not be associated with Mayer-Rokitansky-Kuster-Hauser Syndrome. PMID: 22377151
    22. Single-nucleotide polymorphisms (SNPs) representing 99% coverage of LAMC1 were genotyped. There was no association between SNP rs10911193 and advanced pelvic organ prolapse. There was a trend toward significance for SNPs rs1413390, rs20563, and rs20558. PMID: 22342894
    23. LAMC1 is significantly associated with premature ovarian failure, and specifically, possession of at least one HT1 was associated with susceptibility to premature ovarian failure. PMID: 22321639
    24. Laminin-5 gamma2 chain and SPARC may play roles in the progression of esophageal squamous cell carcinoma and their simultaneous expression is correlated with poorer prognosis. PMID: 21192846
    25. The nano-structure of the laminin gamma-1 short arm was determined. In solution, it adapts an extended conformation. PMID: 20688161
    26. Several LAMC1 single nucleotide polymorphisms exist with significant differences between African American and Caucasian women, but no association found between any LAMC1 variant and advanced pelvic organ prolapse. PMID: 20223449
    27. Enhanced and specialized expression patterns of alpha 1 and gamma 1 laminins distinctly associate these two laminins with the Alzheimer disease. PMID: 12111806
    28. The neurite outgrowth domain of gamma 1 laminin accumulates heavily in the floor plate region, in the notochord and in GFAP-immunoreactive glial fibers of the embryonic spinal cord. PMID: 12526023
    29. Basement membrane formation is inhibited by a nidogen-laminin gamma1-chain fragment in skin-organotypic cultures. PMID: 15159456
    30. Expression of LAMC1 in glioblastoma is inhibited by indomethacin. Indomethacin inhibits cyclooxygenases and is an NSAID drug. PMID: 15561105
    31. a polymorphism in the promoter of LAMC1 may increase the susceptibility to early-onset pelvic organ prolapse PMID: 17021862
    32. gamma1 laminin is selectively overexpressed in reactive astrocytes of the amyotrophic lateral sclerosis spinal cord PMID: 17554784
    33. In embryonic stem cells deficient in laminins, due to lamc1 (laminin gamma1) deletion, vascular development and organization were largely unaffected. PMID: 18073332
    34. Laminin isoforms containing the gamma3 chain are unable to bind to integrins due to the absence of the glutamic acid residue conserved in the C-terminal regions of the gamma1 and gamma2 chains PMID: 18697739

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  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix, basement membrane.
  • 组织特异性：
    Found in the basement membranes (major component).
  • 数据库链接：

    HGNC: 6492

    OMIM: 150290

    KEGG: hsa:3915

    STRING: 9606.ENSP00000258341

    UniGene: Hs.609663