Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. LAMC3 Antibody

LAMC3 Antibody

  • 货号：
    CSB-PA914944
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from K562 cells and 3T3 cells, using LAMC3 antiobdy.
    • Immunohistochemistry analysis of paraffin-embedded human brain tissue using LAMC3 antibody.
    • Immunofluorescence analysis of LOVO cells, using LAMC3 antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) LAMC3 Polyclonal antibody
  • Uniprot No.：
    Q9Y6N6
  • 基因名：
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from internal of Human LAMC3.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
    IF 1:100-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
  • 基因功能参考文献：
    1. LAMC3 gene variation is associated with oral cavity and pharyngeal cancer. PMID: 27749845
    2. We found statistically significant association with AAO for three genes (WRN, NTN4 and LAMC3) with common associated variants. PMID: 26394601
    3. These data suggest that beta2 and gamma3-containing laminins play an important dose-dependent role in development of the cortical pial basement membrane PMID: 22961762
    4. Recessive LAMC3 mutations cause malformations of occipital cortical development. PMID: 21572413
    5. Laminin isoforms containing the gamma3 chain are unable to bind to integrins due to the absence of the glutamic acid residue conserved in the C-terminal regions of the gamma1 and gamma2 chains PMID: 18697739

    显示更多

    收起更多

  • 相关疾病：
    Cortical malformations occipital (OCCM)
  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix, basement membrane.
  • 组织特异性：
    Broadly expressed in: skin, heart, lung, and the reproductive tracts.
  • 数据库链接：

    HGNC: 6494

    OMIM: 604349

    KEGG: hsa:10319

    STRING: 9606.ENSP00000354360

    UniGene: Hs.201805