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LAMP3 Antibody

  • 货号：
    CSB-PA008859
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of MCF7 cells using DC-LAMP Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q9UQV4
  • 基因名：
    LAMP3
  • 别名：
    CD208 antibody; CD208 antigen antibody; DC LAMP antibody; DC lysosome associated membrane glycoprotein antibody; DC-lysosome-associated membrane glycoprotein antibody; DCLAMP antibody; LAMP antibody; LAMP 3 antibody; LAMP-3 antibody; Lamp3 antibody; LAMP3_HUMAN antibody; Lysosomal associated membrane protein 3 antibody; Lysosomal-associated membrane protein 3 antibody; Lysosome-associated membrane glycoprotein 3 antibody; Protein TSC403 antibody; TSC403 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human DC-LAMP.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Lysosomal membrane glycoprotein which plays a role in the unfolded protein response (UPR) that contributes to protein degradation and cell survival during proteasomal dysfunction. Plays a role in the process of fusion of the lysosome with the autophagosome, thereby modulating the autophagic process. Promotes hepatocellular lipogenesis through activation of the PI3K/Akt pathway. May also play a role in dendritic cell function and in adaptive immunity.; (Microbial infection) Plays a positive role in post-entry steps of influenza A virus replication, either virus uncoating, cytosolic transport, or nuclear import of viral components, and promotes nuclear accumulation of influenza nucleoprotein/NP at early stages of viral infection.; (Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F.; (Microbial infection) Promotes the intracellular proliferation of Salmonella typhimuium.
  • 基因功能参考文献：
    1. Knockdown of LAMP3 significantly inhibited OS cell viability and promoted apoptosis. TP53, which is involved in the apoptosis pathway, was found to be highly upregulated after knockdown of LAMP3. PMID: 30008754
    2. LAMP3 promotes the invasion of osteosarcoma cells via SPP1 signaling. PMID: 28849219
    3. mRNA and protein levels of LAMP3 were significantly higher in oral squamous carcinoma tissues than in adjacent normal tissues. High LAMP3 expression was linked to the degree of tumor differentiation and stage. PMID: 28607528
    4. LAMP3 variants found to be associated with Bipolar disorder or Schizophrenia in other populations are also associated with Bipolar disorder risk in Latinos. PMID: 27759212
    5. this study shows that the vitamin D3 reduce the LAMP3 expression during the dendritic cells differentiation and maturation, via NFkappaB pathways PMID: 27697285
    6. Immunohistochemical results showed that high lysosome-associated membrane protein 3 cytoplasmic expression was significantly related to tumor grade ( p = 0.038), lymph node metastasis ( p = 0.049), metastasis ( p < 0.001), level of CA125 ( p = 0.030), and International Federation of Gynecology and Obstetrics (FIGO) ( p < 0.001). PMID: 28349821
    7. study indicates that LAMP-3 is induced by Salmonella infection and recruited to the Salmonella pathogen for intracellular proliferation. PMID: 27329040
    8. In laryngeal squamous cell carcinoma, high LAMP3 and high TP53 protein expression was significantly associated with tumor stage and size and patients with high expression of these proteins had poor overall survival. PMID: 26191259
    9. our results suggest that epithelial LAMP3 expression is an independent prognostic biomarker for esophageal squamous cell carcinoma . PMID: 26263981
    10. LAMP3 gene expression is relevant for prognosis in squamous cell carcinoma of head and neck. PMID: 24634103
    11. LAMP3 and TP53 protein expression was significantly higher in cancerous gastrointestinal tissues compared to normal and benign tissues; only LAMP3 expression correlated with poor overall survival PMID: 25362357
    12. LAMP3 regulation as part of the unfolded protein response contributes to protein degradation and cell survival during proteasomal dysfunction. PMID: 25681212
    13. the PERK/ATF4/LAMP3-arm of the UPR is an additional pathway mediating hypoxia-induced breast cancer cell migration PMID: 23294542
    14. the MCCC1/LAMP3 gene can decrease the risk of Parkinson disease in Chinese population. PMID: 24631562
    15. Increase in CD208+ dendritic cells in tonsils is associated with immunoglobulin A nephropathy PMID: 24081865
    16. LAMP3 knockdown in MCF7 breast cancer cells increases tamoxifen sensitivity. PMID: 24434718
    17. the association between hypoxia, metastasis, and poor prognosis is due, in part, to hypoxic activation of the unfolded protein response and expression of LAMP3. PMID: 24045183
    18. LAMP3 is a driver of interferon related genes as demonstrated by siRNA experiments and by gene expression in cervical carcer samples. PMID: 23651994
    19. These results suggest that Treg-DC interactions may promote chronic H. pylori infection by rendering gastric DCs tolerogenic. PMID: 23876802
    20. DC-LAMP and DC-SIGN may be involved in the pathogenesis of condyloma acuminatum. PMID: 23569139
    21. The crystal structure of the conserved domain of human DC-LAMP was solved. PMID: 22809326
    22. LAMP3 is an influenza A virus inducible gene, and plays an important role in viral post-entry steps. PMID: 21810281
    23. In the current breast cancer cohorts, LAMP3 had independent prognostic value. PMID: 21319150
    24. Both DC-LAMP and DC-SIGN proteins may be involved in the pathogenesis of psoriasis vulgaris. PMID: 21596034
    25. Data show that the ABCA3 N-terminus is proteolytically removed inside acidic LAMP3-positive vesicles MVB/LB. PMID: 20863830
    26. Findings indicate that LAMP3 overexpression is associated with an enhanced metastatic potential and may be a prognostic factor for cervical cancer. PMID: 16204031
    27. LAMP-1 and DC-LAMP antigen chimeras follow different trafficking pathways, induce distinct modulatory immune responses, and are able to present cryptic epitopes. PMID: 16887987
    28. DC-LAMP staining was lost in solid type adenocarcinomas but persisted in well-differentiated areas and there was no prognostic difference in tumors that reacted with DC-LAMP. PMID: 17056097
    29. DC-LAMP has a role in preventing the progression of micrometastatic melanoma in lymph nodes PMID: 17606713
    30. In rheumatoid arthritis patients, the number of CD304(+) plasmacytoid DCs (pDCs) exceeded that of CD1c(+) myeloid DCs (mDCs), with the majority of infiltrating DCs being CD83(-) or DC-LAMP(-). PMID: 18292234
    31. Because a defect of the granular layer in psoriatic lesions has been recognized, increased expression of lysosome-related CD208 in the basal and suprabasal keratinocytes of psoriatic lesions might represent aberrant epidermal differentiation. PMID: 19335688

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  • 亚细胞定位：
    Cell surface. Lysosome membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Early endosome membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    LAMP family
  • 组织特异性：
    Detected in tonsil interdigitating dendritic cells, in spleen, lymph node, Peyer's patches in the small instestine, in thymus medulla and in B-cells (at protein level). Expressed in lymphoid organs and dendritic cells. Expressed in lung. Up-regulated in c
  • 数据库链接：

    HGNC: 14582

    OMIM: 605883

    KEGG: hsa:27074

    STRING: 9606.ENSP00000265598

    UniGene: Hs.518448