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LANCL1 Antibody

  • 货号：
    CSB-PA012742LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Mouse Brain tissue lysate, Mouse Kidney tissue lysate, Mouse skeletal muscle tissue lysate, Mous Liver tissue lysate, Rat Kidney tissue lysate, Rat Heart tissue lysate, A549 whole cell lysate, Hela whole cell lysate, HepG2 whole cell lysate
      All lanes: LANCL1 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 42 kDa
      Observed band size: 42 kDa
    • IHC image of CSB-PA012742LA01HU diluted at 1:300 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) LANCL1 Polyclonal antibody
  • Uniprot No.：
    O43813
  • 基因名：
    LANCL1
  • 别名：
    40 kDa erythrocyte membrane protein antibody; G protein-coupled receptor 69A antibody; GPR69A antibody; LanC (bacterial lantibiotic synthetase component C) like 1 antibody; LanC lantibiotic synthetase component C like 1 (bacterial) antibody; LanC-like protein 1 antibody; LANC1_HUMAN antibody; LANCL1 antibody; p40 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human LanC-like protein 1 protein (50-150AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，LANCL1 Antibody (CSB-PA012742LA01HU)，的标记方式是Non-conjugated。对于LANCL1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA012742LB01HU LANCL1 Antibody, HRP conjugated ELISA
    FITC CSB-PA012742LC01HU LANCL1 Antibody, FITC conjugated
    Biotin CSB-PA012742LD01HU LANCL1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Functions as glutathione transferase. Catalyzes conjugation of the glutathione (GSH) to artificial substrates 1-chloro-2,4-dinitrobenzene (CDNB) and p-nitrophenyl acetate. Mitigates neuronal oxidative stress during normal postnatal development and in response to oxidative stresses probably through GSH antioxidant defense mechanism. May play a role in EPS8 signaling. Binds glutathione.
  • 基因功能参考文献：
    1. Lanthionine synthetase C-like protein 1 interacts with and inhibits cystathionine beta-synthase: a target for neuronal antioxidant defense. PMID: 22891245
    2. the crystal structures of human LanCL1, both free of and complexed with glutathione, revealing glutathione binding to a zinc ion at the putative active site formed by conserved GxxG motifs PMID: 19528316
  • 亚细胞定位：
    Cytoplasm. Cell membrane; Peripheral membrane protein.
  • 蛋白家族：
    LanC-like protein family
  • 组织特异性：
    Detected in erythrocytes, brain, kidney, testis, ovary, heart, lung, placenta and spleen (at protein level). Ubiquitous. Strongly expressed in brain, spinal cord, pituitary gland, kidney, heart, skeletal muscle, pancreas, ovary and testis.
  • 数据库链接：

    HGNC: 6508

    OMIM: 604155

    KEGG: hsa:10314

    STRING: 9606.ENSP00000233714

    UniGene: Hs.13351