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LANCL2 Antibody

  • 货号：
    CSB-PA865129LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: A549 whole cell lysate, U87 whole cell lysate
      All lanes: LANCL2 antibody at 3.5µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 51 kDa
      Observed band size: 51 kDa
    • IHC image of CSB-PA865129LA01HU diluted at 1:300 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of HepG2 cells with CSB-PA865129LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) LANCL2 Polyclonal antibody
  • Uniprot No.：
    Q9NS86
  • 基因名：
    LANCL2
  • 别名：
    G protein coupled receptor 69B antibody; GPR69B antibody; LanC (bacterial lantibiotic synthetase component C) like 2 antibody; LanC-like protein 2 antibody; LANC2_HUMAN antibody; LANCL2 antibody; TASP antibody; Testis specific adriamycin sensitivity protein antibody; Testis-specific adriamycin sensitivity protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human LanC-like protein 2 protein (2-106AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，LANCL2 Antibody (CSB-PA865129LA01HU)，的标记方式是Non-conjugated。对于LANCL2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA865129LB01HU LANCL2 Antibody, HRP conjugated ELISA
    FITC CSB-PA865129LC01HU LANCL2 Antibody, FITC conjugated
    Biotin CSB-PA865129LD01HU LANCL2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes.
  • 基因功能参考文献：
    1. human LANCL2 is a non-transmembrane G protein-coupled receptor susceptible to hormone-induced nuclear translocation. PMID: 27222287
    2. Data indicate that lanthionine synthetase C-like 2 (LanCL2) depletion sensitizes cells to apoptosis through down-regulating serine/threonine protein kinase Akt phosphorylation. PMID: 25273559
    3. human recombinant LANCL2 binds abscisic acid (ABA) directly and provide the first demonstration of ABA binding to a mammalian ABA receptor. PMID: 22037458
    4. Molecular docking studies predict that ABA and other PPAR gamma agonists (e.g., rosiglitazone and pioglitazone) share a binding site on the surface of LANCL2. PMID: 20512604
    5. cDNA cloned and characterized. May play a role as a component of a peptide-modifying complex PMID: 11762191
    6. Lanthionine synthetase components C-like 2 increases cellular sensitivity to adriamycin by decreasing the expression of P-glycoprotein through a transcription-mediated mechanism. PMID: 12566319
    7. Data show that lanthionine synthetase C-like protein (LANCL2) is required for abscisic acid binding on human granulocyte membranes and that LANCL2 is necessary for transduction of the ABA signal into granulocytes and rat insulinoma cells. PMID: 19667068

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Cell membrane.
  • 蛋白家族：
    LanC-like protein family
  • 组织特异性：
    Expressed in brain and testis.
  • 数据库链接：

    HGNC: 6509

    OMIM: 612919

    KEGG: hsa:55915

    STRING: 9606.ENSP00000254770

    UniGene: Hs.595384