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LAT2 Antibody

  • 货号：
    CSB-PA145350
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA145350(LAT2 Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q9GZY6
  • 基因名：
    LAT2
  • 别名：
    HSPC046 antibody; LAB antibody; LAT2 antibody; Linker for activation of B cells antibody; Linker for activation of B-cells antibody; Linker for activation of T cells family member 2 antibody; Linker for activation of T cells transmembrane adaptor 2 antibody; Linker for activation of T-cells family member 2 antibody; Membrane associated adapter molecule antibody; Membrane-associated adapter molecule antibody; Non T cell activation linker antibody; Non-T-cell activation linker antibody; NTAL_HUMAN antibody; WBSCR 5 antibody; Wbscr15 antibody; Williams Beuren syndrome chromosome region 15 antibody; Williams Beuren syndrome chromosome region 5 antibody; Williams-Beuren syndrome chromosomal region 15 protein antibody; Williams-Beuren syndrome chromosomal region 5 protein antibody; WSCR5 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Fusion protein of Human LAT2
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:10-1:50
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.
  • 基因功能参考文献：
    1. Its overexpression represents a negative prognostic marker that has been linked to tumor grade, proliferating potential and angiogenesis and mediates intracellular transport of anticancer agents. PMID: 28815339
    2. The AML1/ETO target gene LAT2 interferes with differentiation of normal hematopoietic precursor cells. PMID: 24456692
    3. LAT2 is an early mediator of the anti-leukemic activity of alkylphospholipids and arsenic trioxide. Thus, LAT2 may be used as a target for the design of drugs for cancer therapy. PMID: 23001822
    4. NTAL acts as a tumor suppressor that enhances the proximal signaling of leukemic blasts. The key downstream molecule responsible for the biological effect of TCR signaling is ERK. PMID: 22269118
    5. LAB has the ability to modulate signaling in virtually every type of leukocyte. PMID: 20643813
    6. LAT2 protein (NTAL) participates in the activation of the c-Met-Grb2-ERK-cPLA2 signalling cascade at early stages of H. pylori infection. PMID: 19879355
    7. data show that NTAL (non-T cell activation linker) appears to be a structural and possibly also functional homologue of LAT (linker for activation of T cells)in non-T cells [non-T cell activation linker] PMID: 12486104
    8. LAB links BCR engagement to downstream signaling pathways. PMID: 12514734
    9. LAB was primarily phosphorylated on three membrane-distal tyrosines, Tyr(136), Tyr(193), and Tyr(233). Mutation of these three tyrosines abolished Grb2 binding and LAB function PMID: 14722116
    10. LAB resembled a LAT molecule unable to bind phospholipase C-gamma1. PMID: 15153499
    11. The NTAL/LAB is expressed in a variety of immune cells. PMID: 15745852
    12. NTAL acts as a negative regulator of TNF-alpha and IL-8 production after stimulation via TREM-1 PMID: 17277102
    13. observations reported herein support the conclusion that NTAL may be differentially utilized by specific receptors for relaying alternative signals and this suggests a flexibility in the function of TRAPs not previously appreciated. PMID: 17993265
    14. These data show that natural killer cell immunoreceptor tyrosine-based activation motifs preferentially use a signaling cassette regulated by interplay between LAT and LAB. PMID: 18645037
    15. expression separates T lineage leukemias into two subgroups with good and poor prognostic outcome to prednisone therapy in acute lymphoblastic leukemia in children PMID: 19183565

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  • 相关疾病：
    LAT2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of LAT2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
  • 亚细胞定位：
    Cell membrane; Single-pass type III membrane protein. Note=Present in lipid rafts.
  • 组织特异性：
    Highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B-cells, NK cells and monocytes. Absent from T-cells (at protein level).
  • 数据库链接：

    HGNC: 12749

    OMIM: 605719

    KEGG: hsa:7462

    STRING: 9606.ENSP00000275635

    UniGene: Hs.741249