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LCOR Antibody

  • 货号：
    CSB-PA856960LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, MCF-7 whole cell lysate, A549 whole cell lysate
      All lanes: LCOR antibody at 4.6μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 48, 45, 107 kDa
      Observed band size: 48 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) LCOR Polyclonal antibody
  • Uniprot No.：
    Q96JN0
  • 基因名：
    LCOR
  • 别名：
    A630025C20RIK antibody; C10orf12 antibody; FLJ38026 antibody; KIAA1795 antibody; LCoR antibody; LCOR_HUMAN antibody; Ligand dependent corepressor antibody; Ligand dependent nuclear receptor corepressor antibody; Ligand-dependent corepressor antibody; Mblk1 related protein 2 antibody; Mblk1-related protein 2 antibody; MLR2 antibody; RP11 175O19.1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Ligand-dependent corepressor protein (13-144AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，LCOR Antibody (CSB-PA856960LA01HU)，的标记方式是Non-conjugated。对于LCOR Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA856960LB01HU LCOR Antibody, HRP conjugated ELISA
    FITC CSB-PA856960LC01HU LCOR Antibody, FITC conjugated
    Biotin CSB-PA856960LD01HU LCOR Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR.
  • 基因功能参考文献：
    1. Taken together, these results provide new insights into the mechanism of action of LCoR and RIP140 and highlight their strong interplay for the control of gene expression and cell proliferation in breast cancer cells. PMID: 28414308
    2. miR-199a promotes stem cell properties in mammary stem cells and breast cancer stem cells by directly repressing nuclear receptor corepressor LCOR, which primes interferon responses. PMID: 28530657
    3. LCoR recruitment by KLF6 regulates expression of the cyclin-dependent kinase inhibitor CDKN1A gene. PMID: 22277651
    4. Ligand-dependent corepressor acts as a novel androgen receptor corepressor, inhibits prostate cancer growth, and is functionally inactivated by the Src protein kinase. PMID: 21856747
    5. These results showed that the presence of miR-615-3p repressed the expression of LCoR, a derepressor of peroxisome proliferator-activated receptor gamma (PPARgamma). PMID: 21565892
    6. Data show that LCoR (ligand-dependent nuclear receptor corepressor) represents a class of corepressor that attenuates agonist-activated nuclear receptor signaling by multiple mechanisms [Ligand-dependent nuclear receptor corepressor]. PMID: 12535528
    7. HDAC6 can function as a cofactor of LCoR but they can act to enhance expression of specific estrogen-regulated genes PMID: 19744931
    8. role for LCoR and CtBP1 as attenuators of progesterone-regulated transcription, but LCoR and CtBP1 can act to enhance transcription of some genes PMID: 19744932

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 29503

    OMIM: 607698

    KEGG: hsa:84458

    STRING: 9606.ENSP00000348298

    UniGene: Hs.427927