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  4. LETMD1 Antibody

LETMD1 Antibody

  • 货号：
    CSB-PA053347
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA053347(LETMD1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA053347(LETMD1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q6P1Q0
  • 基因名：
    LETMD1
  • 别名：
    LETMD1LETM1 domain-containing protein 1 antibody; Cervical cancer 1 proto-oncogene protein p40 antibody; Cervical cancer proto-oncogene 2 protein antibody; HCCR-1 antibody; HCRR-2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Fusion protein of Human LETMD1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in tumorigenesis and may function as a negative regulator of the p53/TP53.
  • 基因功能参考文献：
    1. Data show that the activation of STAT3 protein upregulated human cervical cancer oncogene (HCCR) expression in gastric cancer cells. PMID: 27052330
    2. Demonstrate that HBx-HCCR-E-cadherin regulation pathway might play an important role in HBV-induced hepatocarcinogenesis. PMID: 26470691
    3. These findings suggest that HCCR gene is over-expressed in acute leukemia patients and may be a useful biomarker for monitoring minimal residual disease. PMID: 25034723
    4. HCCR2 gene plays an important role in the tumorigenesis of leukemia. PMID: 24126909
    5. HCCRBP-3 induces tumorigenesis through direct interaction with HCCR-1 in human cancers. PMID: 22851403
    6. The data demonstrate that HCCR-1 may be used as a novel predictor for the prognosis of the patients with esophageal squamous cell carcinoma. PMID: 22511601
    7. HCCR-1 might play a role in the breast tumourigenesis while the overexpression of HCCR-1 induces the obesity probably by inhibiting the cholesterol-lowering effect of ApoE PMID: 20196787
    8. The overexpression of HCCR-2 could enhance the division and proliferation of SMMC 7721 cells. PMID: 21138632
    9. induces neoplastic cell transformation and epithelial-mesenchymal transdifferentiation PMID: 20591135
    10. Treatment of PANC-1 cells with epidermal growth factor increased HCCR-1 protein level via PI3K/Akt/mTOR signaling. PMID: 20423485
    11. Human, similar to bacterial ribosomal protein L14 and yeast L22, gene L14.22 (clone 507E08), over-expressed in gliomas. PMID: 12061725
    12. HCCR-2 probably represents a new oncogene that is related to tumorigenesis, functioning as a negative regulator of the p53 tumor suppressor PMID: 12879013
    13. HCCR-2 represents an oncoprotein that is related to breast cancer development and regulation of the p53 tumor suppressor. PMID: 14691448
    14. HCCR oncoprotein has a role in development of human breast cancer PMID: 16278390
    15. These results suggest that the HCCR-1 oncogene expression was regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway. PMID: 16949218
    16. These experiments show the biological features of HCCR-1 in the cell, and suggest that uncontrolled expression of HCCR-1 may cause mitochondrial dysfunction. PMID: 18045496
    17. Data indicate that the level of HCCR-1 in breast cancer tissues is correlated with the HER2 overexpression, p53 mutation, and ER/PR status, and determination of HCCR-1 levels as options for HER2 testing is promising although it needs further evaluation. PMID: 19208263
    18. TCF and beta-catenin binding plays important roles in HCCR-1 oncogene expression. PMID: 19435525

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  • 亚细胞定位：
    Mitochondrion outer membrane; Single-pass membrane protein.
  • 组织特异性：
    Kidney, liver, skeletal muscle, heart and brain. Overexpressed in various tumors including leukemia, lymphoma, and carcinomas of the breast, kidney, ovary, stomach, colon and uterine cervix.
  • 数据库链接：

    HGNC: 24241

    KEGG: hsa:25875

    STRING: 9606.ENSP00000262055

    UniGene: Hs.655272