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LGALS2 Antibody

  • 货号：
    CSB-PA012886GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P05162
  • 基因名：
    LGALS2
  • 别名：
    Beta galactoside binding lectin L14 II antibody; Beta-galactoside-binding lectin L-14-II antibody; CBP35 antibody; Gal-2 antibody; GAL3 antibody; GALBP antibody; Galectin 2 antibody; Galectin-2 antibody; GALIG antibody; HL14 antibody; Lactose binding lectin 2 antibody; Lactose-binding lectin 2 antibody; LEG2_HUMAN antibody; LGALS2 antibody; MAC2 antibody; S Lac lectin 2 antibody; S-Lac lectin 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Human LGALS2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    This protein binds beta-galactoside. Its physiological function is not yet known.
  • 基因功能参考文献：
    1. Study observed decreased methylation at the DHCR24 locus in offspring of women with active pregnancy eating disorders (ED) and increased methylation at the LGALS2 locus in offspring of women with past ED compared to controls. PMID: 29093763
    2. Data show that lactose binding to galectin-2 (Gal-2) stabilizes the lectin's conformation. PMID: 27563008
    3. Gal-3 was significantly downregulated only in the extravillous trophoblast of intrauterine growth restriction ( IUGR) placentas. In contrast, expressions of gal-2 and gal-13 were downregulated in both villous and extravillous trophoblast cells of IUGR placentas. PMID: 27070577
    4. Galectin-2 binding to different circulating human monocyte subsets depends on monocyte surface expression levels of CD14. It skews human macrophages to a M1-like proinflammatory phenotype. PMID: 25884209
    5. PPARG rs1152002, AGTR1 rs5186, CXCL16 rs3744700 and LGALS2 rs7291467 polymorphisms may be closely related to the development of coronary heart disease PMID: 26045830
    6. Lower LGALS2 gene expression is associated with acute myeloid leukemia. PMID: 25953264
    7. Data suggest that expression of galectin 2 and galectin 2 mRNA is down-regulated in placental extravillous trophoblast and decidua in women with pre-eclampsia as compared to women with normal term pregnancy. PMID: 25707742
    8. The increased circulation of galectins -2, -4 and -8 in cancer patients contributes substantially to the increased circulation of G-CSF, IL-6 and MCP-1 by interaction with the blood vascular endothelium PMID: 24384681
    9. Cys57Met (single-site) mutant and its monoPEGylated derivative can markedly reduce binding of galectin-2 to physiological binding sites PMID: 23581621
    10. results identify galectin-2 as a novel inhibitor of arteriogenesis and its modulation may constitute a new therapeutic strategy for the stimulation of arteriogenesis in patients with coronary artery disease. PMID: 21831908
    11. LTA and LGALS2 polymorphisms affect the subclinical phenotype of the coronary artery, which predisposes to the incidence of myocardial infarction. PMID: 22310064
    12. low expression of galectin-2 was significantly associated with lymph node metastasis and advanced clinical stage in patients with gastric cancer PMID: 22015694
    13. These results suggested differences in the inflammatory response to malaria in children and adults with polymorphisms of the galectin-2 gene. PMID: 20500087
    14. the LTA gene and LGALS2-C3279T are not associated with coronary artery disease PMID: 19726041
    15. Our case-control association study in a Japanese population showed that a single nucleotide polymorphism in LGALS2 encoding galectin-2 is significantly associated with susceptibility to myocardial infarction PMID: 15129282
    16. This study classifies galectin-2 as proapoptotic effector for activated T cells, raising a therapeutic perspective. PMID: 15356130
    17. Fasting plasma glucose and serum insulin were statistically significantly associated with LGALS2 PMID: 16468038
    18. Galectin 2 induces surface phosphatidylserine exposure in a carbohydrate-dependent fashion in activated, but not resting, human neutrophils and in several leukocyte cell lines. PMID: 16940423
    19. no significant association of allele frequency with risk of myocardial infarction PMID: 17098239
    20. polymorphism of LGALS2 was not associated with the severity of coronary atherosclerosis in Japanese and Korean populations PMID: 17493152
    21. Data show that galectin-2 SNPs are not associated with myocardial infarction in two different German populations. PMID: 17497114
    22. Galectin-2 was present in nuclei of Geneti-cally engineered human colon carcinoma cells with stable ectopic expression. PMID: 17999373
    23. Data show that genotypes for the 3279C-->T polymorphism (rs7291467) of LGALS2 was associated (P<0.05) with the prevalence of atherothrombotic cerebral infarction. PMID: 18506375
    24. Galectin-2 (LGALS2) 3279C/T polymorphism may be independently associated with diastolic blood pressure in patients with rheumatoid arthritis. PMID: 19330599
    25. Galectin-2 is strongly expressed in inflammatory skin of autoimmune-prone transgenic mice, indicating that galectin-2 is up-regulated upon experimental cutaneous inflammation. PMID: 19380789

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  • 数据库链接：

    HGNC: 6562

    OMIM: 150571

    KEGG: hsa:3957

    STRING: 9606.ENSP00000215886

    UniGene: Hs.531776