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LGALS4 Antibody

  • 货号：
    CSB-PA787674
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from HeLa cells, using LEG7 antibody.
    • Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue using LEG4 antiobdy.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) LGALS4 Polyclonal antibody
  • Uniprot No.：
    P56470
  • 基因名：
    LGALS4
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from internal of Human LEG4.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions.
  • 基因功能参考文献：
    1. Data show that galectin-4 expressing tumor cells interact directly with red blood cells (RBCs). PMID: 28293788
    2. Haplotype formed from two promoter SNPs rs116896264 and rs73933062 is associated with galectin-4 overexpression in colorectal cancer. PMID: 26681582
    3. LGALS4 may function as a tumor suppressor gene in UC progression. Findings provide evidence that methylation-mediated LGALS4 gene repression may be involved in urothelial tumor progression. PMID: 28423602
    4. Together, the data demonstrated that surface-bound galectin-4 is a dual function protein-down-regulating cell proliferation and chemokine secretion in galectin-4-expressing colorectal cancer cells on one hand and inducing apoptosis in galectin-4-negative colorectal cancer cells on the other hand. PMID: 28345468
    5. The carbohydrate-binding site is composed of residues His236, Asn238, Arg240, Asn249, Trp256, Glu259 and Lys261 at the strands S4, S5 and S6. PMID: 26432949
    6. The data suggests that arm-Gal4 has detrimental effects on Drosophila development and lifespan that are directly dependent upon parental inheritance PMID: 26505429
    7. The co-expression of galectin-4 and CNT3 proteins is not impaired in inflamed colon from patients with Crohn's disease, thereby anticipating the integrity of this system for drug targeting. PMID: 26481311
    8. Structural characterization of human galectin 4 C-terminal domain in terms its ligands binding specificity has been reported. PMID: 26077389
    9. role in basolateral to apical epithelial transcytosis PMID: 25179596
    10. The results show galectin-4 expression closely associates with hepatocellular carcinoma (HCC) progression and might have potential use as a prognostic biomarker for HCC patients. PMID: 25230111
    11. Galectin-4 plays an important role in metastatic process of lung adenocarcinoma. PMID: 24339976
    12. Data indicate that galectin-4 elicits tumor promotion in vitro and in vivo through activation of IL-6/NF-kappaB/STAT3 signaling. PMID: 23378274
    13. Loss of Galectin-4 is associated with colorectal cancer. PMID: 21064109
    14. crystals of galectin-4 belonged to space group P6(1)22, with unit-cell parameters a = b = 71.25, c = 108.66 A. PMID: 20445255
    15. microarray study in sinonasal adenocarcinoma we identified proteins, LGALS4 that is significantly differentially expressed in tumors compared to normal tissue PMID: 19903339
    16. results suggest that galectin-4 has a unique carbohydrate binding specificity and interacts with O-linked sulfoglycans PMID: 11971864
    17. SB1a and CEA in the patches on the cell surface of human colon adenocarcinoma cells could be biologically important ligands for galectin-4 PMID: 15546874
    18. Together, our data propose that interaction between galectin-4 and sulfatides plays a functional role in the clustering of lipid rafts for apical delivery. PMID: 15883199
    19. Galectin 4 induces surface phosphatidylserine exposure in a carbohydrate-dependent fashion in activated, but not resting, human neutrophils and in several leukocyte cell lines. PMID: 16940423
    20. not only sulfated glycosphingolipids but also cholesterol 3-sulfate are endogenous ligands for galectin-4 in vivo PMID: 17545668
    21. chemical analysis of talose-selectivity of galectin-4 and galectin-8 PMID: 18539029
    22. Data show that the pattern of N-glycosylation of glycoproteins serves as a recognition signal for endocytosed galectin-4, which drives the raft-dependent apical pathway of glycoproteins in enterocyte-like HT-29 cells. PMID: 19192249

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  • 数据库链接：

    HGNC: 6565

    OMIM: 602518

    KEGG: hsa:3960

    STRING: 9606.ENSP00000302100

    UniGene: Hs.5302