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LHPP Antibody

  • 货号：
    CSB-PA867114HA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA867114HA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) LHPP Polyclonal antibody
  • Uniprot No.：
    Q9H008
  • 基因名：
  • 别名：
    FLJ44846 antibody; FLJ46044 antibody; HDHD2B antibody; hLHPP antibody; lhpp antibody; LHPP_HUMAN antibody; Phospholysine phosphohistidine inorganic pyrophosphate phosphatase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Phospholysine phosphohistidine inorganic pyrophosphate phosphatase protein (1-270AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，LHPP Antibody (CSB-PA867114HA01HU)，的标记方式是Non-conjugated。对于LHPP Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA867114HB01HU LHPP Antibody, HRP conjugated ELISA
    FITC CSB-PA867114HC01HU LHPP Antibody, FITC conjugated
    Biotin CSB-PA867114HD01HU LHPP Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Phosphatase that hydrolyzes imidodiphosphate, 3-phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency.
  • 基因功能参考文献：
    1. LHPP suppresses cell proliferation and metastasis in cervical cancer, and promotes apoptosis by suppressing AKT activation. PMID: 29944886
    2. in patients with hepatocellular carcinoma, low expression of LHPP correlated with increased tumour severity and reduced overall survival; thus LHPP is a protein histidine phosphatase and tumour suppressor, suggesting that deregulated histidine phosphorylation is oncogenic PMID: 29562234
    3. LHPP is associated with the interplay of risky sexual behaviors and alcohol dependence. PMID: 27531626
    4. Patients with major depressive disorder with LHPP rs35936514 CT/TT genotype have increased activity in certain brain regions. PMID: 27843651
    5. LHPP gene variation is associated with oral cavity and pharyngeal cancer. PMID: 27749845
    6. Lhpp or a product of a collinear brain-specific transcript, therefore, may interact with Htr1a in the pathogenesis of major depression PMID: 18268499

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    HAD-like hydrolase superfamily
  • 组织特异性：
    Expressed in brain, and at lower levels in liver and kidney. Detected in thyroid (at protein level). Expressed in liver, kidney and moderately in brain.
  • 数据库链接：

    HGNC: 30042

    OMIM: 617231

    KEGG: hsa:64077

    STRING: 9606.ENSP00000357835

    UniGene: Hs.527748